Next Article in Journal
Synthesis of a Cleaved Form of Osteopontin by THP-1 Cells and Its Alteration by Phorbol 12-Myristate 13-Acetate and BCG Infection
Next Article in Special Issue
The Optimal PEG for Kidney Preservation: A Preclinical Porcine Study
Previous Article in Journal
A Pathological Study of Acute Pulmonary Toxicity Induced by Inhaled Kanto Loam Powder
Previous Article in Special Issue
Acute Limb Ischemia—Much More Than Just a Lack of Oxygen
Open AccessReview

Interplay between ROS and Antioxidants during Ischemia-Reperfusion Injuries in Cardiac and Skeletal Muscle

Radiologic Sciences and Respiratory Therapy Division, School of Health and Rehabilitation Sciences, The Ohio State University College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA
Interdisciplinary Biophysics Graduate Program, The Ohio State University, Columbus, OH 43210, USA
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(2), 417;
Received: 21 November 2017 / Revised: 14 January 2018 / Accepted: 21 January 2018 / Published: 31 January 2018
Ischemia reperfusion (IR), present in myocardial infarction or extremity injuries, is a major clinical issue and leads to substantial tissue damage. Molecular mechanisms underlying IR injury in striated muscles involve the production of reactive oxygen species (ROS). Excessive ROS accumulation results in cellular oxidative stress, mitochondrial dysfunction, and initiation of cell death by activation of the mitochondrial permeability transition pore. Elevated ROS levels can also decrease myofibrillar Ca2+ sensitivity, thereby compromising muscle contractile function. Low levels of ROS can act as signaling molecules involved in the protective pathways of ischemic preconditioning (IPC). By scavenging ROS, antioxidant therapies aim to prevent IR injuries with positive treatment outcomes. Novel therapies such as postconditioning and pharmacological interventions that target IPC pathways hold great potential in attenuating IR injuries. Factors such as aging and diabetes could have a significant impact on the severity of IR injuries. The current paper aims to provide a comprehensive review on the multifaceted roles of ROS in IR injuries, with a focus on cardiac and skeletal muscle, as well as recent advancement in ROS-related therapies. View Full-Text
Keywords: contraction; ischemic preconditioning; free radicals; cytochrome c contraction; ischemic preconditioning; free radicals; cytochrome c
Show Figures

Graphical abstract

MDPI and ACS Style

Zhou, T.; Prather, E.R.; Garrison, D.E.; Zuo, L. Interplay between ROS and Antioxidants during Ischemia-Reperfusion Injuries in Cardiac and Skeletal Muscle. Int. J. Mol. Sci. 2018, 19, 417.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map

Back to TopTop