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Interstitial Fluid in Gynecologic Tumors and Its Possible Application in the Clinical Practice

Institute for Maternal and Child Health—IRCCS “Burlo Garofolo”, 34137 Trieste, Italy
Department of Medical, Surgery and Health Sciences, University of Trieste, 34137 Trieste, Italy
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(12), 4018;
Received: 15 November 2018 / Accepted: 29 November 2018 / Published: 12 December 2018
Gynecologic cancers are an important cause of worldwide mortality. The interstitium consists of solid and fluid phases, situated between the blood vessels and cells. The interstitial fluid (IF), or fluid phase, is an extracellular fluid bathing and surrounding the tissue cells. The TIF (tumor interstitial fluid) is a dynamic fluid rich in lipids, proteins and enzyme-derived substances. The molecules found in the IF may be associated with pathological changes in tissues leading to cancer growth and metastatization. Proteomic techniques have allowed an extensive study of the composition of the TIF as a source of biomarkers for gynecologic cancers. In our review, we analyze the composition of the TIF, its formation process, the sampling methods, the consequences of its accumulation and the proteomic analyses performed, that make TIF valuable for monitoring different types of cancers. View Full-Text
Keywords: tumor interstitial fluid; gynecologic tumors; proteomics; biomarker tumor interstitial fluid; gynecologic tumors; proteomics; biomarker
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MDPI and ACS Style

Ura, B.; Di Lorenzo, G.; Romano, F.; Monasta, L.; Mirenda, G.; Scrimin, F.; Ricci, G. Interstitial Fluid in Gynecologic Tumors and Its Possible Application in the Clinical Practice. Int. J. Mol. Sci. 2018, 19, 4018.

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