Small Noncoding Regulatory RNAs from Pseudomonas aeruginosa and Burkholderia cepacia Complex
iBB-Institute for Bioengineering and Biosciences, Departmento de Bioengenharia, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, Torre Sul, Piso 6, 1049-001 Lisbon, Portugal
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Int. J. Mol. Sci. 2018, 19(12), 3759; https://doi.org/10.3390/ijms19123759
Received: 31 October 2018
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Revised: 22 November 2018
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Accepted: 23 November 2018
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Published: 27 November 2018
(This article belongs to the Special Issue Microbial Virulence Factors)
Cystic fibrosis (CF) is the most life-limiting autosomal recessive disorder in Caucasians. CF is characterized by abnormal viscous secretions that impair the function of several tissues, with chronic bacterial airway infections representing the major cause of early decease of these patients. Pseudomonas aeruginosa and bacteria from the Burkholderia cepacia complex (Bcc) are the leading pathogens of CF patients’ airways. A wide array of virulence factors is responsible for the success of infections caused by these bacteria, which have tightly regulated responses to the host environment. Small noncoding RNAs (sRNAs) are major regulatory molecules in these bacteria. Several approaches have been developed to study P. aeruginosa sRNAs, many of which were characterized as being involved in the virulence. On the other hand, the knowledge on Bcc sRNAs remains far behind. The purpose of this review is to update the knowledge on characterized sRNAs involved in P. aeruginosa virulence, as well as to compile data so far achieved on sRNAs from the Bcc and their possible roles on bacteria virulence.
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Keywords:
cystic fibrosis; Pseudomonas aeruginosa; Burkholderia cepacia complex; small noncoding regulatory RNAs; pathogenicity
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MDPI and ACS Style
Pita, T.; Feliciano, J.R.; Leitão, J.H. Small Noncoding Regulatory RNAs from Pseudomonas aeruginosa and Burkholderia cepacia Complex. Int. J. Mol. Sci. 2018, 19, 3759. https://doi.org/10.3390/ijms19123759
AMA Style
Pita T, Feliciano JR, Leitão JH. Small Noncoding Regulatory RNAs from Pseudomonas aeruginosa and Burkholderia cepacia Complex. International Journal of Molecular Sciences. 2018; 19(12):3759. https://doi.org/10.3390/ijms19123759
Chicago/Turabian StylePita, Tiago, Joana R. Feliciano, and Jorge H. Leitão. 2018. "Small Noncoding Regulatory RNAs from Pseudomonas aeruginosa and Burkholderia cepacia Complex" International Journal of Molecular Sciences 19, no. 12: 3759. https://doi.org/10.3390/ijms19123759
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