Targeting Smoothened as a New Frontier in the Functional Recovery of Central Nervous System Demyelinating Pathologies
Abstract
:1. Introduction
2. Shh Signaling during CNS Remyelination
3. Shh/Smo Signaling During OPC Differentiation
4. Smo and Gli-Associated Oncogene Regulation in Adult Somatic Cells
4.1. Smo and Gli Antagonists
4.2. Canonical Pathways of Gli Regulation
4.3. Non-Canonical Pathways of Gli Regulation
5. Shh Signaling, Cholesterol Biosynthesis and Myelination: A Complex Liaison
6. Concluding Remarks
Acknowledgments
Conflict of interest
References
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Del Giovane, A.; Ragnini-Wilson, A. Targeting Smoothened as a New Frontier in the Functional Recovery of Central Nervous System Demyelinating Pathologies. Int. J. Mol. Sci. 2018, 19, 3677. https://doi.org/10.3390/ijms19113677
Del Giovane A, Ragnini-Wilson A. Targeting Smoothened as a New Frontier in the Functional Recovery of Central Nervous System Demyelinating Pathologies. International Journal of Molecular Sciences. 2018; 19(11):3677. https://doi.org/10.3390/ijms19113677
Chicago/Turabian StyleDel Giovane, Alice, and Antonella Ragnini-Wilson. 2018. "Targeting Smoothened as a New Frontier in the Functional Recovery of Central Nervous System Demyelinating Pathologies" International Journal of Molecular Sciences 19, no. 11: 3677. https://doi.org/10.3390/ijms19113677