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BDNF, Brain, and Regeneration: Insights from Zebrafish

1
Department of Veterinary Medicine, University of Naples Federico II, 80137 Naples, Italy
2
Stazione Zoologica Anton Dohrn, 80122 Naples, Italy
3
Centro Ricerche Interdipartimentali sui Biomateriali, University of Naples FedericoII, 80125 Naples, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(10), 3155; https://doi.org/10.3390/ijms19103155
Received: 26 September 2018 / Revised: 10 October 2018 / Accepted: 11 October 2018 / Published: 13 October 2018
(This article belongs to the Special Issue Brain-Derived Neurotrophic Factor 2018)
Zebrafish (Danio rerio) is a teleost fish widely accepted as a model organism for neuroscientific studies. The adults show common basic vertebrate brain structures, together with similar key neuroanatomical and neurochemical pathways of relevance to human diseases. However, the brain of adult zebrafish possesses, differently from mammals, intense neurogenic activity, which can be correlated with high regenerative properties. Brain derived neurotrophic factor (BDNF), a member of the neurotrophin family, has multiple roles in the brain, due also to the existence of several biologically active isoforms, that interact with different types of receptors. BDNF is well conserved in the vertebrate evolution, with the primary amino acid sequences of zebrafish and human BDNF being 91% identical. Here, we review the available literature regarding BDNF in the vertebrate brain and the potential involvement of BDNF in telencephalic regeneration after injury, with particular emphasis to the zebrafish. Finally, we highlight the potential of the zebrafish brain as a valuable model to add new insights on future BDNF studies. View Full-Text
Keywords: Fish; neuroregeneration; neurotrophins; Trk B; p75 Fish; neuroregeneration; neurotrophins; Trk B; p75
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Lucini, C.; D’Angelo, L.; Cacialli, P.; Palladino, A.; De Girolamo, P. BDNF, Brain, and Regeneration: Insights from Zebrafish. Int. J. Mol. Sci. 2018, 19, 3155.

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