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Int. J. Mol. Sci. 2018, 19(10), 3131;

Relationship between Serum BDNF Levels and Depressive Mood in Subacute Stroke Patients: A Preliminary Study

Department of Physical and Rehabilitation Medicine, Center for Prevention and Rehabilitation, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea
Department of Health Science and Technology, Department of Medical Device Management & Research, Department of Digital Health, SAIHST, Sungkyunkwan University, Seoul 06351, Korea
Author to whom correspondence should be addressed.
Received: 19 September 2018 / Revised: 9 October 2018 / Accepted: 10 October 2018 / Published: 12 October 2018
(This article belongs to the Special Issue Brain-Derived Neurotrophic Factor 2018)
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The aim of this preliminary study was to investigate the potential of serum brain-derived neurotrophic factor (BDNF) as a biomarker in poststroke depressive mood in subacute stroke patients. Thirty-eight subacute stroke patients were recruited in this study. All participants underwent the standard rehabilitation program that included 2 h of physical therapy daily and 1 h of occupational therapy five days a week. The rehabilitation period lasted two weeks during the subacute stroke phase. We measured the serum BDNF, proBDNF, and matrix metalloproteinase-9 before and one and two weeks after the standard rehabilitation program. In addition, all participants were assessed using the Geriatric Depression Scale-Short Form (GDS-SF) for depressive mood at three time points. Pearson correlation analysis was performed to determine the relationship between serum BDNF levels and the GDS-SF. The GDS-SF showed significant improvement during the standard rehabilitation program period (p < 0.05). The GDS-SF was significantly correlated with serum BDNF levels at each time point (p < 0.05). These results suggest that serum BDNF may be used as a biomarker for depressive mood in subacute stroke patients. However, further studies with larger study populations are needed to clarify these results. View Full-Text
Keywords: BDNF; neurotrophic factor; stroke; depression BDNF; neurotrophic factor; stroke; depression

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Chang, W.H.; Shin, M.A.; Lee, A.; Kim, H.; Kim, Y.-H. Relationship between Serum BDNF Levels and Depressive Mood in Subacute Stroke Patients: A Preliminary Study. Int. J. Mol. Sci. 2018, 19, 3131.

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