Next Article in Journal
Membrane-Bound Class III Peroxidases: Unexpected Enzymes with Exciting Functions
Next Article in Special Issue
Studies on Silver Ions Releasing Processes and Mechanical Properties of Surface-Modified Titanium Alloy Implants
Previous Article in Journal
Thioredoxin Confers Intrinsic Resistance to Cytostatic Drugs in Human Glioma Cells
Article

Polydopamine-Assisted Silver Nanoparticle Self-Assembly on Sericin/Agar Film for Potential Wound Dressing Application

1
State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400715, China
2
College of Biotechnology, Southwest University, Chongqing 400715, China
3
College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China
4
Chongqing Key Laboratory of Sericultural Science, Chongqing Engineering and Technology Research Center for Novel Silk Materials, Southwest University, Chongqing 400715, China
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(10), 2875; https://doi.org/10.3390/ijms19102875
Received: 23 August 2018 / Revised: 16 September 2018 / Accepted: 19 September 2018 / Published: 21 September 2018
(This article belongs to the Special Issue Silver Nano/microparticles: Modification and Applications)
Silver nanoparticles (AgNPs) are extensively applied for their broad-spectrum and excellent antibacterial ability in recent years. Polydopamine (PDA) has great advantages for synthesizing large amounts of AgNPs, as it has multiple sites for silver ion binding and phenolic hydroxyl structure to reduce silver ions to AgNPs. Here, we mixed sericin and agar solution and dried at 65 °C to prepare a sericin (SS)/Agar composite film, and then coated polydopamine (PDA) on the surface of SS/Agar film by soaking SS/Agar film into polydopamine solution, subsequently synthesizing high-density AgNPs with the assistance of PDA to yield antibacterial AgNPs-PDA- SS/Agar film. Scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) spectra indicated the successful synthesis of high-density AgNPs on the surface of PDA-SS/Agar film. PDA coating and AgNPs modification did not affect the structure of sericin and agar. Furthermore, water contact angle, water absorption and mechanical property analysis showed that AgNPs-PDA-SS/Agar film had excellent hydrophilicity and proper mechanical properties. Inhibition zone and growth curve assays suggested the prepared film had excellent and long-lasting antibacterial ability. In addition, it had excellent cytocompatibility on the fibroblast NIH/3T3 cells. The film shows great potential as a novel kind of wound dressing. View Full-Text
Keywords: polydopamine; silver nanoparticle; sericin; antimicrobial activity; cytocompatibility polydopamine; silver nanoparticle; sericin; antimicrobial activity; cytocompatibility
Show Figures

Figure 1

MDPI and ACS Style

Liu, L.; Cai, R.; Wang, Y.; Tao, G.; Ai, L.; Wang, P.; Yang, M.; Zuo, H.; Zhao, P.; He, H. Polydopamine-Assisted Silver Nanoparticle Self-Assembly on Sericin/Agar Film for Potential Wound Dressing Application. Int. J. Mol. Sci. 2018, 19, 2875. https://doi.org/10.3390/ijms19102875

AMA Style

Liu L, Cai R, Wang Y, Tao G, Ai L, Wang P, Yang M, Zuo H, Zhao P, He H. Polydopamine-Assisted Silver Nanoparticle Self-Assembly on Sericin/Agar Film for Potential Wound Dressing Application. International Journal of Molecular Sciences. 2018; 19(10):2875. https://doi.org/10.3390/ijms19102875

Chicago/Turabian Style

Liu, Liying, Rui Cai, Yejing Wang, Gang Tao, Lisha Ai, Peng Wang, Meirong Yang, Hua Zuo, Ping Zhao, and Huawei He. 2018. "Polydopamine-Assisted Silver Nanoparticle Self-Assembly on Sericin/Agar Film for Potential Wound Dressing Application" International Journal of Molecular Sciences 19, no. 10: 2875. https://doi.org/10.3390/ijms19102875

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop