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Int. J. Mol. Sci. 2018, 19(1), 184; https://doi.org/10.3390/ijms19010184

Fungicidal PMMA-Undecylenic Acid Composites

1
Powder Technology Laboratory, Institute of Materials, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland
2
Faculty of Medicine, University of Nis, 18006 Niš, Serbia
*
Author to whom correspondence should be addressed.
Received: 1 December 2017 / Revised: 24 December 2017 / Accepted: 1 January 2018 / Published: 8 January 2018
(This article belongs to the Section Biochemistry)
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Abstract

Undecylenic acid (UA), known as antifungal agent, still cannot be used to efficiently modify commercial dental materials in such a way that this affects Candida. Actually, issues with Candida infections and fungal resistance compromise the use of Poly(methyl-methacrylate) (PMMA) as dental material. The challenge remains to turn PMMA into an antifugal material, which can ideally affect both sessile (attached) and planktonic (free-floating) Candida cells. We aimed to tackle this challenge by designing PMMA-UA composites with different UA concentrations (3–12%). We studied their physico-chemical properties, the antifungal effect on Candida and the cytotoxicity toward human cells. We found that UA changes the PMMA surface into a more hydrophilic one. Mainly, as-preparation composites with ≥6% UA reduced sessile Candida for >90%. After six days, the composites were still efficiently reducing the sessile Candida cells (for ~70% for composites with ≥6% UA). Similar results were recorded for planktonic Candida. Moreover, the inhibition zone increased along with the UA concentration. The antifungal effect of UA was also examined at the surface of an UA-loaded agar and the minimal inhibitory concentration (MIC90) was below the lowest-studied 0.0125% UA. Furthermore, the embedded filamentation test after 24 h and 48 h showed complete inhibition of the Candida growth at 0.4% UA. View Full-Text
Keywords: undecylenic acid; PMMA; antifungal; fungicidal; anti-Candida; Candida albicans undecylenic acid; PMMA; antifungal; fungicidal; anti-Candida; Candida albicans
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Petrović, M.; Bonvin, D.; Hofmann, H.; Mionić Ebersold, M. Fungicidal PMMA-Undecylenic Acid Composites. Int. J. Mol. Sci. 2018, 19, 184.

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