Potential Roles of Intrinsic Disorder in Maternal-Effect Proteins Involved in the Maintenance of DNA Methylation
AbstractDNA methylation is an important epigenetic modification that needs to be carefully controlled as a prerequisite for normal early embryogenesis. Compelling evidence now suggests that four maternal-effect proteins, primordial germ cell 7 (PGC7), zinc finger protein 57 (ZFP57), tripartite motif-containing 28 (TRIM28) and DNA methyltransferase (cytosine-5) 1 (DNMT1) are involved in the maintenance of DNA methylation. However, it is still not fully understood how these maternal-effect proteins maintain the DNA methylation imprint. We noticed that a feature common to these proteins is the presence of significant levels of intrinsic disorder so in this study we started from an intrinsic disorder perspective to try to understand these maternal-effect proteins. To do this, we firstly analysed the intrinsic disorder predispositions of PGC7, ZFP57, TRIM28 and DNMT1 by using a set of currently available computational tools and secondly conducted an intensive literature search to collect information on their interacting partners and structural characterization. Finally, we discuss the potential effect of intrinsic disorder on the function of these proteins in maintaining DNA methylation. View Full-Text
- Supplementary File 1:
Supplementary (ZIP, 511 KB)
Share & Cite This Article
Liu, H.; Wei, Q.; Huang, C.; Zhang, Y.; Guo, Z. Potential Roles of Intrinsic Disorder in Maternal-Effect Proteins Involved in the Maintenance of DNA Methylation. Int. J. Mol. Sci. 2017, 18, 1898.
Liu H, Wei Q, Huang C, Zhang Y, Guo Z. Potential Roles of Intrinsic Disorder in Maternal-Effect Proteins Involved in the Maintenance of DNA Methylation. International Journal of Molecular Sciences. 2017; 18(9):1898.Chicago/Turabian Style
Liu, Hongliang; Wei, Qing; Huang, Chenyang; Zhang, Yong; Guo, Zekun. 2017. "Potential Roles of Intrinsic Disorder in Maternal-Effect Proteins Involved in the Maintenance of DNA Methylation." Int. J. Mol. Sci. 18, no. 9: 1898.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.