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Open AccessCase Report

Speechlessness in Gilles de la Tourette Syndrome: Cannabis-Based Medicines Improve Severe Vocal Blocking Tics in Two Patients

Department of Psychiatry, Socialpsychiatry and Psychotherapy, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany
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Int. J. Mol. Sci. 2017, 18(8), 1739; https://doi.org/10.3390/ijms18081739
Received: 25 May 2017 / Revised: 24 June 2017 / Accepted: 3 August 2017 / Published: 10 August 2017
(This article belongs to the Special Issue Cannabinoid Signaling in Nervous System)
We report the cases of two young German male patients with treatment-resistant Tourette syndrome (TS), who suffer from incapacitating stuttering-like speech disfluencies caused by vocal blocking tics and palilalia. Case 1: a 19-year old patient received medical cannabis at a dose of 1 × 0.1 g cannabis daily. Case 2: a 16-year old patient initially received dronabinol at a maximum dose of 22.4–33.6 mg daily. Both treatments provided significant symptom improvement of vocal blocking tics as well as of comorbid conditions and were well tolerated. Thus, cannabis-based medicine appears to be effective in treatment-resistant TS patients with vocal blocking tics. View Full-Text
Keywords: Tourette syndrome; tics; nabiximols; blocking tics; dysfluency; cannabis Tourette syndrome; tics; nabiximols; blocking tics; dysfluency; cannabis
MDPI and ACS Style

Jakubovski, E.; Müller-Vahl, K. Speechlessness in Gilles de la Tourette Syndrome: Cannabis-Based Medicines Improve Severe Vocal Blocking Tics in Two Patients. Int. J. Mol. Sci. 2017, 18, 1739.

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