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Modulation of Astrocyte Activity by Cannabidiol, a Nonpsychoactive Cannabinoid

by Ewa Kozela 1,2,*, Ana Juknat 1,2 and Zvi Vogel 1,2
1
The Dr Miriam and Sheldon G. Adelson Center for the Biology of Addictive Diseases, Sackler Faculty of Medicine, Tel Aviv University, 6997801 Tel Aviv, Israel
2
Neurobiology Department, Weizmann Institute of Science, 76100 Rehovot, Israel
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2017, 18(8), 1669; https://doi.org/10.3390/ijms18081669
Received: 10 July 2017 / Revised: 26 July 2017 / Accepted: 26 July 2017 / Published: 31 July 2017
(This article belongs to the Special Issue Cannabinoid Signaling in Nervous System)
The astrocytes have gained in recent decades an enormous interest as a potential target for neurotherapies, due to their essential and pleiotropic roles in brain physiology and pathology. Their precise regulation is still far from understood, although several candidate molecules/systems arise as promising targets for astrocyte-mediated neuroregulation and/or neuroprotection. The cannabinoid system and its ligands have been shown to interact and affect activities of astrocytes. Cannabidiol (CBD) is the main non-psychotomimetic cannabinoid derived from Cannabis. CBD is devoid of direct CB1 and CB2 receptor activity, but exerts a number of important effects in the brain. Here, we attempt to sum up the current findings on the effects of CBD on astrocyte activity, and in this way on central nervous system (CNS) functions, across various tested models and neuropathologies. The collected data shows that increased astrocyte activity is suppressed in the presence of CBD in models of ischemia, Alzheimer-like and Multiple-Sclerosis-like neurodegenerations, sciatic nerve injury, epilepsy, and schizophrenia. Moreover, CBD has been shown to decrease proinflammatory functions and signaling in astrocytes. View Full-Text
Keywords: cannabidiol; cannabinoid; astrocyte; neurodegeneration; neuroinflammation cannabidiol; cannabinoid; astrocyte; neurodegeneration; neuroinflammation
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Kozela, E.; Juknat, A.; Vogel, Z. Modulation of Astrocyte Activity by Cannabidiol, a Nonpsychoactive Cannabinoid. Int. J. Mol. Sci. 2017, 18, 1669.

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