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miRNAs in Normal and Malignant Hematopoiesis

Department of Hematology and Oncology, Tokai University School of Medicine, Hiratsuka 259-1193, Japan
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2017, 18(7), 1495;
Received: 1 May 2017 / Revised: 21 June 2017 / Accepted: 25 June 2017 / Published: 11 July 2017
(This article belongs to the Special Issue microRNA Regulation 2017)
Lineage specification is primarily regulated at the transcriptional level and lineage-specific transcription factors determine cell fates. MicroRNAs (miRNAs) are 18–24 nucleotide-long non-coding RNAs that post-transcriptionally decrease the translation of target mRNAs and are essential for many cellular functions. miRNAs also regulate lineage specification during hematopoiesis. This review highlights the roles of miRNAs in B-cell development and malignancies, and discusses how miRNA expression profiles correlate with disease prognoses and phenotypes. We also discuss the potential for miRNAs as therapeutic targets and diagnostic tools for B-cell malignancies. View Full-Text
Keywords: miRNA; lymphoma; leukemia; B-cell miRNA; lymphoma; leukemia; B-cell
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MDPI and ACS Style

Kotaki, R.; Koyama-Nasu, R.; Yamakawa, N.; Kotani, A. miRNAs in Normal and Malignant Hematopoiesis. Int. J. Mol. Sci. 2017, 18, 1495.

AMA Style

Kotaki R, Koyama-Nasu R, Yamakawa N, Kotani A. miRNAs in Normal and Malignant Hematopoiesis. International Journal of Molecular Sciences. 2017; 18(7):1495.

Chicago/Turabian Style

Kotaki, Ryutaro; Koyama-Nasu, Ryo; Yamakawa, Natsuko; Kotani, Ai. 2017. "miRNAs in Normal and Malignant Hematopoiesis" Int. J. Mol. Sci. 18, no. 7: 1495.

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