Int. J. Mol. Sci. 2017, 18(6), 1302; https://doi.org/10.3390/ijms18061302
Suppression of Ghrelin Exacerbates HFCS-Induced Adiposity and Insulin Resistance
Xiaojun Ma 1,2,†, Ligen Lin 2,3,†
, Jing Yue 2,4,†, Chia-Shan Wu 5, Cathy A. Guo 5, Ruitao Wang 6, Kai-Jiang Yu 6, Sridevi Devaraj 7, Peter Murano 5, Zheng Chen 8 and Yuxiang Sun 2,5,*
, Jing Yue 2,4,†, Chia-Shan Wu 5, Cathy A. Guo 5, Ruitao Wang 6, Kai-Jiang Yu 6, Sridevi Devaraj 7, Peter Murano 5, Zheng Chen 8 and Yuxiang Sun 2,5,*
1
Department of Internal Medicine, Zhengzhou University, Zhengzhou 450052, China
2
Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
3
State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macau 999078, China
4
Department of Reproductive Medicine, Huazhong Science and Technology University, Wuhan 430030, China
5
Department of Nutrition and Food Science, Texas A&M University, College Station, TX 77843, USA
6
Department of Internal Medicine, Harbin Medical University, Harbin 150081, China
7
Department of Pathology and Immunology, Baylor College of Medicine; Houston, TX 77030, USA
8
Department of Biochemistry and Molecular Biology, University of Texas Health Science Center, Houston, TX 77030, USA
†
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 28 April 2017 / Revised: 11 June 2017 / Accepted: 12 June 2017 / Published: 19 June 2017
(This article belongs to the Special Issue Gene-Diet Interactions in Chronic Diseases)
Abstract
High fructose corn syrup (HFCS) is widely used as sweetener in processed foods and soft drinks in the United States, largely substituting sucrose (SUC). The orexigenic hormone ghrelin promotes obesity and insulin resistance; ghrelin responds differently to HFCS and SUC ingestion. Here we investigated the roles of ghrelin in HFCS- and SUC-induced adiposity and insulin resistance. To mimic soft drinks, 10-week-old male wild-type (WT) and ghrelin knockout (Ghrelin−/−) mice were subjected to ad lib. regular chow diet supplemented with either water (RD), 8% HFCS (HFCS), or 10% sucrose (SUC). We found that SUC-feeding induced more robust increases in body weight and body fat than HFCS-feeding. Comparing to SUC-fed mice, HFCS-fed mice showed lower body weight but higher circulating glucose and insulin levels. Interestingly, we also found that ghrelin deletion exacerbates HFCS-induced adiposity and inflammation in adipose tissues, as well as whole-body insulin resistance. Our findings suggest that HFCS and SUC have differential effects on lipid metabolism: while sucrose promotes obesogenesis, HFCS primarily enhances inflammation and insulin resistance, and ghrelin confers protective effects for these metabolic dysfunctions. View Full-TextKeywords:
ghrelin; HFCS; sucrose; fructose; glucose; adiposity; insulin resistance; adipose tissue inflammation
▼
Figures
Figure 1
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
Share & Cite This Article
MDPI and ACS Style
Ma, X.; Lin, L.; Yue, J.; Wu, C.-S.; Guo, C.A.; Wang, R.; Yu, K.-J.; Devaraj, S.; Murano, P.; Chen, Z.; Sun, Y. Suppression of Ghrelin Exacerbates HFCS-Induced Adiposity and Insulin Resistance. Int. J. Mol. Sci. 2017, 18, 1302.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.
Related Articles
Article Metrics
Comments
[Return to top]
Int. J. Mol. Sci.
EISSN 1422-0067
Published by MDPI AG, Basel, Switzerland
RSS
E-Mail Table of Contents Alert