ADAR1 and MicroRNA; A Hidden Crosstalk in Cancer
AbstractThe evolution of cancer cells is believed to be dependent on genetic or epigenetic alterations. However, this concept has recently been challenged by another mode of nucleotide alteration, RNA editing, which is frequently up-regulated in cancer. RNA editing is a biochemical process in which either Adenosine or Cytosine is deaminated by a group of RNA editing enzymes including ADAR (Adenosine deaminase; RNA specific) or APOBEC3B (Apolipoprotein B mRNA Editing Enzyme Catalytic Subunit 3B). The result of RNA editing is usually adenosine to inosine (A-to-I) or cytidine to uridine (C-to-U) transition, which can affect protein coding, RNA stability, splicing and microRNA-target interactions. The functional impact of these alterations is largely unclear and is a subject of extensive research. In the present review, we will specifically focus on the influence of ADARs on carcinogenesis via the regulation of microRNA processing and functioning. This follows a brief review of the current knowledge of properties of ADAR enzyme, RNA editing, and microRNA processing. View Full-Text
Share & Cite This Article
Cho, C.J.; Myung, S.-J.; Chang, S. ADAR1 and MicroRNA; A Hidden Crosstalk in Cancer. Int. J. Mol. Sci. 2017, 18, 799.
Cho CJ, Myung S-J, Chang S. ADAR1 and MicroRNA; A Hidden Crosstalk in Cancer. International Journal of Molecular Sciences. 2017; 18(4):799.Chicago/Turabian Style
Cho, Charles J.; Myung, Seung-Jae; Chang, Suhwan. 2017. "ADAR1 and MicroRNA; A Hidden Crosstalk in Cancer." Int. J. Mol. Sci. 18, no. 4: 799.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.