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Emerging Roles of IL-33/ST2 Axis in Renal Diseases

Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan
Division of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan
Author to whom correspondence should be addressed.
Academic Editor: Alan Parrish
Int. J. Mol. Sci. 2017, 18(4), 783;
Received: 17 March 2017 / Revised: 29 March 2017 / Accepted: 5 April 2017 / Published: 7 April 2017
(This article belongs to the Special Issue Advances in Chronic Kidney Disease 2017)
Renal diseases, including acute kidney injury (AKI) and chronic kidney disease (CKD), have a great impact on health care systems worldwide. Similar to cardiovascular diseases, renal diseases are inflammatory diseases involving a variety of cytokines. Primary causes of renal injury include ischemia, uremic toxins, bacteremia, or nephrotoxicity. Inflammation represents an important component following kidney injury. Interleukin (IL)-33 is a member of the IL-1 cytokine family, which is widely expressed in epithelial barrier tissues and endothelial cells, and mediates both tissue inflammation and repair responses. IL-33 is released as a nuclear alarmin in response to tissue damage and triggers innate and adaptive immune responses by binding to its receptor, suppression of tumorigenicity 2 (ST2). Recent evidence from clinical and experimental animal studies indicates that the IL-33/ST2 axis is involved in the pathogenesis of CKD, renal graft injury, systemic lupus nephritis, and AKI. In this review, we discuss the pathological and tissue reparative roles of the IL-33/ST2 pathway in different types of renal diseases. View Full-Text
Keywords: interleukin-33; chronic renal disease; acute renal injury; inflammation interleukin-33; chronic renal disease; acute renal injury; inflammation
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MDPI and ACS Style

Chen, W.-Y.; Li, L.-C.; Yang, J.-L. Emerging Roles of IL-33/ST2 Axis in Renal Diseases. Int. J. Mol. Sci. 2017, 18, 783.

AMA Style

Chen W-Y, Li L-C, Yang J-L. Emerging Roles of IL-33/ST2 Axis in Renal Diseases. International Journal of Molecular Sciences. 2017; 18(4):783.

Chicago/Turabian Style

Chen, Wei-Yu, Lung-Chih Li, and Jenq-Lin Yang. 2017. "Emerging Roles of IL-33/ST2 Axis in Renal Diseases" International Journal of Molecular Sciences 18, no. 4: 783.

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