Next Article in Journal
Differential Proteome Analysis of a Flor Yeast Strain under Biofilm Formation
Next Article in Special Issue
Potentials of Long Noncoding RNAs (LncRNAs) in Sarcoma: From Biomarkers to Therapeutic Targets
Previous Article in Journal
It Is Imperative to Establish a Pellucid Definition of Chimeric RNA and to Clear Up a Lot of Confusion in the Relevant Research
Previous Article in Special Issue
Evaluation and Adaptation of a Laboratory-Based cDNA Library Preparation Protocol for Retrospective Sequencing of Archived MicroRNAs from up to 35-Year-Old Clinical FFPE Specimens
Article Menu
Issue 4 (April) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2017, 18(4), 715;

Function and Clinical Implications of Long Non-Coding RNAs in Melanoma

Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz 8010, Austria
Department of Dermatology, Medical University of Graz, Graz 8036, Austria
Institute for Pathology, Medical University of Graz, Graz 8036, Austria
Division of Hematology, Department of Internal Medicine, Medical University of Graz, Graz 8036, Austria
Faculty of Medicine, Martin-Luther-University Halle-Wittenberg, Halle (Saale) 06120, Germany
Division of Clinical Oncology, Department of Medicine, Medical University of Graz, Graz 8036, Austria
Authors to whom correspondence should be addressed.
Academic Editor: Andrzej Slominski
Received: 19 February 2017 / Revised: 16 March 2017 / Accepted: 17 March 2017 / Published: 28 March 2017
(This article belongs to the Collection Regulation by Non-Coding RNAs)
Full-Text   |   PDF [704 KB, uploaded 28 March 2017]   |  


Metastatic melanoma is the most deadly type of skin cancer. Despite the success of immunotherapy and targeted agents, the majority of patients experience disease recurrence upon treatment and die due to their disease. Long non-coding RNAs (lncRNAs) are a new subclass of non-protein coding RNAs involved in (epigenetic) regulation of cell growth, invasion, and other important cellular functions. Consequently, recent research activities focused on the discovery of these lncRNAs in a broad spectrum of human diseases, especially cancer. Additional efforts have been undertaken to dissect the underlying molecular mechanisms employed by lncRNAs. In this review, we will summarize the growing evidence of deregulated lncRNA expression in melanoma, which is linked to tumor growth and progression. Moreover, we will highlight specific molecular pathways and modes of action for some well-studied lncRNAs and discuss their potential clinical implications. View Full-Text
Keywords: lncRNA; skin cancer lncRNA; skin cancer

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Richtig, G.; Ehall, B.; Richtig, E.; Aigelsreiter, A.; Gutschner, T.; Pichler, M. Function and Clinical Implications of Long Non-Coding RNAs in Melanoma. Int. J. Mol. Sci. 2017, 18, 715.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top