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A Review of Structure Construction of Silk Fibroin Biomaterials from Single Structures to Multi-Level Structures

National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, China
Nano Fusion Technology Research Lab, Interdisciplinary Cluster for Cutting Edge Research (ICCER), Division of Frontier Fibers, Institute for Fiber Engineering (IFES), Shinshu University, Ueda, Nagano 386 8567, Japan
Authors to whom correspondence should be addressed.
Academic Editors: John G. Hardy and Chris Holland
Int. J. Mol. Sci. 2017, 18(3), 237;
Received: 24 November 2016 / Revised: 5 January 2017 / Accepted: 11 January 2017 / Published: 3 March 2017
(This article belongs to the Special Issue Silk-Based Materials: From Production to Characterization)
The biological performance of artificial biomaterials is closely related to their structure characteristics. Cell adhesion, migration, proliferation, and differentiation are all strongly affected by the different scale structures of biomaterials. Silk fibroin (SF), extracted mainly from silkworms, has become a popular biomaterial due to its excellent biocompatibility, exceptional mechanical properties, tunable degradation, ease of processing, and sufficient supply. As a material with excellent processability, SF can be processed into various forms with different structures, including particulate, fiber, film, and three-dimensional (3D) porous scaffolds. This review discusses and summarizes the various constructions of SF-based materials, from single structures to multi-level structures, and their applications. In combination with single structures, new techniques for creating special multi-level structures of SF-based materials, such as micropatterning and 3D-printing, are also briefly addressed. View Full-Text
Keywords: silk fibroin; structure; biomaterials silk fibroin; structure; biomaterials
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MDPI and ACS Style

Qi, Y.; Wang, H.; Wei, K.; Yang, Y.; Zheng, R.-Y.; Kim, I.S.; Zhang, K.-Q. A Review of Structure Construction of Silk Fibroin Biomaterials from Single Structures to Multi-Level Structures. Int. J. Mol. Sci. 2017, 18, 237.

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