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Protective Effects of ω-3 PUFA in Anthracycline-Induced Cardiotoxicity: A Critical Review

Istituto di Patologia Generale, Università Cattolica del Sacro Cuore, Largo Francesco Vito, 1-00168 Roma, Italy
Center for Translational Research in Oncology (Laboratory of Medical Investigation #24), Department of Radiology and Oncology, School of Medicine of São Paulo University, Cancer Institute of São Paulo, São Paulo 01246-000, Brazil
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2017, 18(12), 2689;
Received: 9 November 2017 / Revised: 29 November 2017 / Accepted: 8 December 2017 / Published: 12 December 2017
(This article belongs to the Special Issue Omega-3 Fatty Acids in Health and Disease: New Knowledge)
It has been demonstrated that ω-3 polyunsaturated fatty acids (ω-3 PUFA) may exert a beneficial role as adjuvants in the prevention and treatment of many disorders, including cardiovascular diseases and cancer. Particularly, several in vitro and in vivo preclinical studies have shown the antitumor activity of ω-3 PUFA in different kinds of cancers, and several human studies have shown that ω-3 PUFA are able to decrease the risk of a series of cardiovascular diseases. Several mechanisms have been proposed to explain their pleiotropic beneficial effects. ω-3 PUFA have also been shown to prevent harmful side-effects (including cardiotoxicity and heart failure) induced by conventional and innovative anti-cancer drugs in both animals and patients. The available literature regarding the possible protective effects of ω-3 PUFA against anthracycline-induced cardiotoxicity, as well as the mechanisms involved, will be critically discussed herein. The study will analyze the critical role of different levels of ω-3 PUFA intake in determining the results of the combinatory studies with anthracyclines. Suggestions for future research will also be considered. View Full-Text
Keywords: anthracyclines; cardioprotection; cardiotoxicity; chemotherapy; ω-3 PUFA anthracyclines; cardioprotection; cardiotoxicity; chemotherapy; ω-3 PUFA
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Serini, S.; Ottes Vasconcelos, R.; Nascimento Gomes, R.; Calviello, G. Protective Effects of ω-3 PUFA in Anthracycline-Induced Cardiotoxicity: A Critical Review. Int. J. Mol. Sci. 2017, 18, 2689.

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