Next Article in Journal
Simvastatin Inhibits Cell Proliferation and Migration in Human Anaplastic Thyroid Cancer
Next Article in Special Issue
ω-3 Long Chain Polyunsaturated Fatty Acids as Sensitizing Agents and Multidrug Resistance Revertants in Cancer Therapy
Previous Article in Journal
The Venom of the Spine-Bellied Sea Snake (Hydrophis curtus): Proteome, Toxin Diversity and Intraspecific Variation
Previous Article in Special Issue
Impact of Omega-3 Fatty Acids on the Gut Microbiota
Article Menu
Issue 12 (December) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2017, 18(12), 2689;

Protective Effects of ω-3 PUFA in Anthracycline-Induced Cardiotoxicity: A Critical Review

Istituto di Patologia Generale, Università Cattolica del Sacro Cuore, Largo Francesco Vito, 1-00168 Roma, Italy
Center for Translational Research in Oncology (Laboratory of Medical Investigation #24), Department of Radiology and Oncology, School of Medicine of São Paulo University, Cancer Institute of São Paulo, São Paulo 01246-000, Brazil
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 9 November 2017 / Revised: 29 November 2017 / Accepted: 8 December 2017 / Published: 12 December 2017
(This article belongs to the Special Issue Omega-3 Fatty Acids in Health and Disease: New Knowledge)
Full-Text   |   PDF [1146 KB, uploaded 12 December 2017]   |  


It has been demonstrated that ω-3 polyunsaturated fatty acids (ω-3 PUFA) may exert a beneficial role as adjuvants in the prevention and treatment of many disorders, including cardiovascular diseases and cancer. Particularly, several in vitro and in vivo preclinical studies have shown the antitumor activity of ω-3 PUFA in different kinds of cancers, and several human studies have shown that ω-3 PUFA are able to decrease the risk of a series of cardiovascular diseases. Several mechanisms have been proposed to explain their pleiotropic beneficial effects. ω-3 PUFA have also been shown to prevent harmful side-effects (including cardiotoxicity and heart failure) induced by conventional and innovative anti-cancer drugs in both animals and patients. The available literature regarding the possible protective effects of ω-3 PUFA against anthracycline-induced cardiotoxicity, as well as the mechanisms involved, will be critically discussed herein. The study will analyze the critical role of different levels of ω-3 PUFA intake in determining the results of the combinatory studies with anthracyclines. Suggestions for future research will also be considered. View Full-Text
Keywords: anthracyclines; cardioprotection; cardiotoxicity; chemotherapy; ω-3 PUFA anthracyclines; cardioprotection; cardiotoxicity; chemotherapy; ω-3 PUFA

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Serini, S.; Ottes Vasconcelos, R.; Nascimento Gomes, R.; Calviello, G. Protective Effects of ω-3 PUFA in Anthracycline-Induced Cardiotoxicity: A Critical Review. Int. J. Mol. Sci. 2017, 18, 2689.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top