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Int. J. Mol. Sci. 2017, 18(12), 2620; https://doi.org/10.3390/ijms18122620

A Looking-Glass of Non-Coding RNAs in Oral Cancer

1
Department of Prosthetic dentistry and Dental materials, Division Dental Propaedeutics, Aesthetic, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, 23 Marinescu Street, 40015 Cluj-Napoca, Romania
2
Research Center for Functional Genomics and Translational Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, 23 Marinescu Street, 40015 Cluj-Napoca, Romania
3
MEDFUTURE-Research Center for Advanced Medicine, University of Medicine and Pharmacy Iuliu-Hatieganu, 23 Marinescu Street, 40015 Cluj-Napoca, Romania
4
Department of Maxillofacial Surgery, Medical University, 3 Hristo Botev Blvd, 4002 Plovdiv, Bulgaria
5
Clinic of Maxillofacial Surgery, University Hospital “St. George”, 66 Peshtersko Shosse Blvd, 4002 Plovdiv, Bulgaria
6
Department of Medical Biology, Medical University Plovdiv, 15-А Vasil Aprilov Bul, 4002 Plovdiv, Bulgaria
7
Prosthetics and Dental materials, Faculty of Dental Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, 32 Clinicilor Street, 400006 Cluj-Napoca, Romania
8
Department of Functional Genomics and Experimental Pathology, The Oncology Institute “Prof. Dr. Ion Chiricuta”, Republicii 34th street, 400015 Cluj-Napoca, Romania
*
Author to whom correspondence should be addressed.
Received: 21 October 2017 / Revised: 10 November 2017 / Accepted: 17 November 2017 / Published: 5 December 2017
(This article belongs to the Section Biochemistry)
Full-Text   |   PDF [2652 KB, uploaded 6 December 2017]   |  

Abstract

Oral cancer is a multifactorial pathology and is characterized by the lack of efficient treatment and accurate diagnostic tools. This is mainly due the late diagnosis; therefore, reliable biomarkers for the timely detection of the disease and patient stratification are required. Non-coding RNAs (ncRNAs) are key elements in the physiological and pathological processes of various cancers, which is also reflected in oral cancer development and progression. A better understanding of their role could give a more thorough perspective on the future treatment options for this cancer type. This review offers a glimpse into the ncRNA involvement in oral cancer, which can help the medical community tap into the world of ncRNAs and lay the ground for more powerful diagnostic, prognostic and treatment tools for oral cancer that will ultimately help build a brighter future for these patients. View Full-Text
Keywords: oral cancer; non-coding RNA; miRNA; lncRNA; piRNA; circRNA oral cancer; non-coding RNA; miRNA; lncRNA; piRNA; circRNA
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Irimie, A.I.; Braicu, C.; Sonea, L.; Zimta, A.A.; Cojocneanu-Petric, R.; Tonchev, K.; Mehterov, N.; Diudea, D.; Buduru, S.; Berindan-Neagoe, I. A Looking-Glass of Non-Coding RNAs in Oral Cancer. Int. J. Mol. Sci. 2017, 18, 2620.

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