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Int. J. Mol. Sci. 2017, 18(12), 2542;

Ionic Substitutions in Non-Apatitic Calcium Phosphates

Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy with Laboratory Medicine Division, Medical University of Warsaw, ul. Banacha 1, 02-097 Warsaw, Poland
Author to whom correspondence should be addressed.
Received: 9 November 2017 / Revised: 22 November 2017 / Accepted: 24 November 2017 / Published: 27 November 2017
(This article belongs to the Special Issue Novel Biomaterials for Tissue Engineering 2018)
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Calcium phosphate materials (CaPs) are similar to inorganic part of human mineralized tissues (i.e., bone, enamel, and dentin). Owing to their high biocompatibility, CaPs, mainly hydroxyapatite (HA), have been investigated for their use in various medical applications. One of the most widely used ways to improve the biological and physicochemical properties of HA is ionic substitution with trace ions. Recent developments in bioceramics have already demonstrated that introducing foreign ions is also possible in other CaPs, such as tricalcium phosphates (amorphous as well as α and β crystalline forms) and brushite. The purpose of this paper is to review recent achievements in the field of non-apatitic CaPs substituted with various ions. Particular attention will be focused on tricalcium phosphates (TCP) and “additives” such as magnesium, zinc, strontium, and silicate ions, all of which have been widely investigated thanks to their important biological role. This review also highlights some of the potential biomedical applications of non-apatitic substituted CaPs. View Full-Text
Keywords: calcium phosphates; ionic substitution; brushite; αTCP; βTCP; bioceramics calcium phosphates; ionic substitution; brushite; αTCP; βTCP; bioceramics

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Laskus, A.; Kolmas, J. Ionic Substitutions in Non-Apatitic Calcium Phosphates. Int. J. Mol. Sci. 2017, 18, 2542.

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