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Int. J. Mol. Sci. 2017, 18(10), 2129;

Control of NK Cell Activation by Immune Checkpoint Molecules

Laboratoire d’Immunologie, Hôpital Henri Mondor, Assistance Publique–Hôpitaux de Paris, 94000 Créteil, France
Centre de Recherches sur l’Inflammation, Institut National de Recherche Médicale (INSERM) UMR1149, Université Paris Diderot, 75013 Paris, France
Laboratoire d’Immunologie, Hôpital Saint-Louis, Assistance Publique–Hôpitaux de Paris, 75010 Paris, France
Author to whom correspondence should be addressed.
Received: 19 September 2017 / Revised: 4 October 2017 / Accepted: 9 October 2017 / Published: 12 October 2017
(This article belongs to the Special Issue Natural Killer (NK) Cells)
Full-Text   |   PDF [252 KB, uploaded 12 October 2017]


The development of cancer and chronic infections is facilitated by many subversion mechanisms, among which enhanced expression of immune checkpoints molecules, such as programmed death-1 (PD-1) and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), on exhausted T cells. Recently, immune checkpoint inhibitors have shown remarkable efficiency in the treatment of a number of cancers. However, expression of immune checkpoints on natural killer (NK) cells and its functional consequences on NK cell effector functions are much less explored. In this review, we focus on the current knowledge on expression of various immune checkpoints in NK cells, how it can alter NK cell-mediated cytotoxicity and cytokine production. Dissecting the role of these inhibitory mechanisms in NK cells is critical for the full understanding of the mode of action of immunotherapies using checkpoint inhibitors in the treatment of cancers and chronic infections. View Full-Text
Keywords: NK cells; immune checkpoint molecules; cancer immunotherapy NK cells; immune checkpoint molecules; cancer immunotherapy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Beldi-Ferchiou, A.; Caillat-Zucman, S. Control of NK Cell Activation by Immune Checkpoint Molecules. Int. J. Mol. Sci. 2017, 18, 2129.

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