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Int. J. Mol. Sci. 2017, 18(1), 10;

Cofilin-1 and Other ADF/Cofilin Superfamily Members in Human Malignant Cells

Laboratory of Biomedical Research, Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Leninsky Prospekt, 33, bld. 2, 119071 Moscow, Russia
Department of Biochemistry, Medical Institute, Peoples’ Friendship University of Russia, Miklukho-Maklaya Street, 6, 117198 Moscow, Russia
Author to whom correspondence should be addressed.
Academic Editor: William Chi-shing Cho
Received: 30 September 2016 / Revised: 18 November 2016 / Accepted: 1 December 2016 / Published: 22 December 2016
(This article belongs to the Special Issue Big Data for Oncology)
Full-Text   |   PDF [2097 KB, uploaded 22 December 2016]   |  


Identification of actin-depolymerizing factor homology (ADF-H) domains in the structures of several related proteins led first to the formation of the ADF/cofilin family, which then expanded to the ADF/cofilin superfamily. This superfamily includes the well-studied cofilin-1 (Cfl-1) and about a dozen different human proteins that interact directly or indirectly with the actin cytoskeleton, provide its remodeling, and alter cell motility. According to some data, Cfl-1 is contained in various human malignant cells (HMCs) and is involved in the formation of malignant properties, including invasiveness, metastatic potential, and resistance to chemotherapeutic drugs. The presence of other ADF/cofilin superfamily proteins in HMCs and their involvement in the regulation of cell motility were discovered with the use of various OMICS technologies. In our review, we discuss the results of the study of Cfl-1 and other ADF/cofilin superfamily proteins, which may be of interest for solving different problems of molecular oncology, as well as for the prospects of further investigations of these proteins in HMCs. View Full-Text
Keywords: cofilin-1; ADF/cofilin superfamily proteins; cell motility; human malignant cells cofilin-1; ADF/cofilin superfamily proteins; cell motility; human malignant cells

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Shishkin, S.; Eremina, L.; Pashintseva, N.; Kovalev, L.; Kovaleva, M. Cofilin-1 and Other ADF/Cofilin Superfamily Members in Human Malignant Cells. Int. J. Mol. Sci. 2017, 18, 10.

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