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Int. J. Mol. Sci. 2016, 17(9), 1401;

Multifaceted Roles of ALG-2 in Ca2+-Regulated Membrane Trafficking

Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan
Author to whom correspondence should be addressed.
Academic Editor: Charles J. Malemud
Received: 21 July 2016 / Revised: 18 August 2016 / Accepted: 19 August 2016 / Published: 26 August 2016
(This article belongs to the Special Issue Metalloproteins 2017)
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ALG-2 (gene name: PDCD6) is a penta-EF-hand Ca2+-binding protein and interacts with a variety of proteins in a Ca2+-dependent fashion. ALG-2 recognizes different types of identified motifs in Pro-rich regions by using different hydrophobic pockets, but other unknown modes of binding are also used for non-Pro-rich proteins. Most ALG-2-interacting proteins associate directly or indirectly with the plasma membrane or organelle membranes involving the endosomal sorting complex required for transport (ESCRT) system, coat protein complex II (COPII)-dependent ER-to-Golgi vesicular transport, and signal transduction from membrane receptors to downstream players. Binding of ALG-2 to targets may induce conformational change of the proteins. The ALG-2 dimer may also function as a Ca2+-dependent adaptor to bridge different partners and connect the subnetwork of interacting proteins. View Full-Text
Keywords: ALG-2; ALIX; calcium; COPII; ESCRT; membrane repair; multivesicular body; PDCD6; protein–protein interaction; Sec31A ALG-2; ALIX; calcium; COPII; ESCRT; membrane repair; multivesicular body; PDCD6; protein–protein interaction; Sec31A

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Maki, M.; Takahara, T.; Shibata, H. Multifaceted Roles of ALG-2 in Ca2+-Regulated Membrane Trafficking. Int. J. Mol. Sci. 2016, 17, 1401.

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