Multifaceted Roles of ALG-2 in Ca2+-Regulated Membrane Trafficking
AbstractALG-2 (gene name: PDCD6) is a penta-EF-hand Ca2+-binding protein and interacts with a variety of proteins in a Ca2+-dependent fashion. ALG-2 recognizes different types of identified motifs in Pro-rich regions by using different hydrophobic pockets, but other unknown modes of binding are also used for non-Pro-rich proteins. Most ALG-2-interacting proteins associate directly or indirectly with the plasma membrane or organelle membranes involving the endosomal sorting complex required for transport (ESCRT) system, coat protein complex II (COPII)-dependent ER-to-Golgi vesicular transport, and signal transduction from membrane receptors to downstream players. Binding of ALG-2 to targets may induce conformational change of the proteins. The ALG-2 dimer may also function as a Ca2+-dependent adaptor to bridge different partners and connect the subnetwork of interacting proteins. View Full-Text
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Maki, M.; Takahara, T.; Shibata, H. Multifaceted Roles of ALG-2 in Ca2+-Regulated Membrane Trafficking. Int. J. Mol. Sci. 2016, 17, 1401.
Maki M, Takahara T, Shibata H. Multifaceted Roles of ALG-2 in Ca2+-Regulated Membrane Trafficking. International Journal of Molecular Sciences. 2016; 17(9):1401.Chicago/Turabian Style
Maki, Masatoshi; Takahara, Terunao; Shibata, Hideki. 2016. "Multifaceted Roles of ALG-2 in Ca2+-Regulated Membrane Trafficking." Int. J. Mol. Sci. 17, no. 9: 1401.
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