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Int. J. Mol. Sci. 2016, 17(7), 1029;

Aquaporins and Brain Tumors

Department of Experimental Biomedicine and Clinical Neurosciences (BIONEC), University of Palermo, Palermo I-90127, Italy
Department of Biological Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo (UNIPA), Palermo I-90128, Italy
Author to whom correspondence should be addressed.
Academic Editor: Kenichi Ishibashi
Received: 20 May 2016 / Revised: 22 June 2016 / Accepted: 22 June 2016 / Published: 29 June 2016
(This article belongs to the Special Issue Aquaporin)
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Brain primary tumors are among the most diverse and complex human cancers, and they are normally classified on the basis of the cell-type and/or the grade of malignancy (the most malignant being glioblastoma multiforme (GBM), grade IV). Glioma cells are able to migrate throughout the brain and to stimulate angiogenesis, by inducing brain capillary endothelial cell proliferation. This in turn causes loss of tight junctions and fragility of the blood–brain barrier, which becomes leaky. As a consequence, the most serious clinical complication of glioblastoma is the vasogenic brain edema. Both glioma cell migration and edema have been correlated with modification of the expression/localization of different isoforms of aquaporins (AQPs), a family of water channels, some of which are also involved in the transport of other small molecules, such as glycerol and urea. In this review, we discuss relationships among expression/localization of AQPs and brain tumors/edema, also focusing on the possible role of these molecules as both diagnostic biomarkers of cancer progression, and therapeutic targets. Finally, we will discuss the possibility that AQPs, together with other cancer promoting factors, can be exchanged among brain cells via extracellular vesicles (EVs). View Full-Text
Keywords: aquaporins (AQPs); brain tumors; glioblastoma multiforme; blood–brain barrier (BBB); extracellular vesicles (EVs) aquaporins (AQPs); brain tumors; glioblastoma multiforme; blood–brain barrier (BBB); extracellular vesicles (EVs)

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Maugeri, R.; Schiera, G.; Di Liegro, C.M.; Fricano, A.; Iacopino, D.G.; Di Liegro, I. Aquaporins and Brain Tumors. Int. J. Mol. Sci. 2016, 17, 1029.

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