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Int. J. Mol. Sci. 2016, 17(5), 789;

Functions of miRNAs during Mammalian Heart Development

Department of Genetics, the University of Alabama at Birmingham, Birmingham, AL 35294, USA
Author to whom correspondence should be addressed.
Academic Editor: Y-h. Taguchi
Received: 30 March 2016 / Revised: 26 April 2016 / Accepted: 13 May 2016 / Published: 21 May 2016
(This article belongs to the Special Issue MicroRNA Regulation)
Full-Text   |   PDF [198 KB, uploaded 21 May 2016]


MicroRNAs (miRNAs) play essential roles during mammalian heart development and have emerged as attractive therapeutic targets for cardiovascular diseases. The mammalian embryonic heart is mainly derived from four major cell types during development. These include cardiomyocytes, endocardial cells, epicardial cells, and neural crest cells. Recent data have identified various miRNAs as critical regulators of the proper differentiation, proliferation, and survival of these cell types. In this review, we briefly introduce the contemporary understanding of mammalian cardiac development. We also focus on recent developments in the field of cardiac miRNAs and their functions during the development of different cell types. View Full-Text
Keywords: miRNA; Dicer1; cardiogenesis miRNA; Dicer1; cardiogenesis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Yan, S.; Jiao, K. Functions of miRNAs during Mammalian Heart Development. Int. J. Mol. Sci. 2016, 17, 789.

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