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Non-Alcoholic Fatty Liver Disease and Extra-Hepatic Cancers

Division of Gastroenterology, Department of Medical Sciences, A.O. Città della Salute e della Scienza di Torino, University of Turin, 10126 Turin, Italy
Author to whom correspondence should be addressed.
Academic Editors: Amedeo Lonardo and Giovanni Targher
Int. J. Mol. Sci. 2016, 17(5), 717;
Received: 5 March 2016 / Revised: 5 May 2016 / Accepted: 9 May 2016 / Published: 12 May 2016
(This article belongs to the Special Issue Non-Alcoholic Fatty Liver Disease Research 2016)
PDF [238 KB, uploaded 12 May 2016]


Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease but the second cause of death among NAFLD patients are attributed to malignancies at both gastrointestinal (liver, colon, esophagus, stomach, and pancreas) and extra-intestinal sites (kidney in men, and breast in women). Obesity and related metabolic abnormalities are associated with increased incidence or mortality for a number of cancers. NAFLD has an intertwined relationship with metabolic syndrome and significantly contributes to the risk of hepatocellular carcinoma (HCC), but recent evidence have fuelled concerns that NAFLD may be a new, and added, risk factor for extra-hepatic cancers, particularly in the gastrointestinal tract. In this review we critically appraise key studies on NAFLD-associated extra-hepatic cancers and speculate on how NAFLD may influence carcinogenesis at these sites. View Full-Text
Keywords: fatty liver; colorectal cancer; adipokines; gut microbiota fatty liver; colorectal cancer; adipokines; gut microbiota

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Sanna, C.; Rosso, C.; Marietti, M.; Bugianesi, E. Non-Alcoholic Fatty Liver Disease and Extra-Hepatic Cancers. Int. J. Mol. Sci. 2016, 17, 717.

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