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Int. J. Mol. Sci. 2016, 17(5), 685;

Connecting the Dots: From DNA Damage and Repair to Aging

Graduate Institute of Clinical Medicine, College of Medicine, Kaohsoung Medical University, Kaohsiung 807, Taiwan
The Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
Department of Systems Biology, MD Anderson Cancer Center, Houston, TX 77030, USA
National Institute of Cancer Research, National Health Research Institutes, Tainan 704, Taiwan
Author to whom correspondence should be addressed.
Academic Editor: Guillermo T. Sáez
Received: 23 March 2016 / Revised: 19 April 2016 / Accepted: 3 May 2016 / Published: 6 May 2016
(This article belongs to the Special Issue DNA Damage and Repair in Degenerative Diseases 2016)
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Mammalian cells evolve a delicate system, the DNA damage response (DDR) pathway, to monitor genomic integrity and to prevent the damage from both endogenous end exogenous insults. Emerging evidence suggests that aberrant DDR and deficient DNA repair are strongly associated with cancer and aging. Our understanding of the core program of DDR has made tremendous progress in the past two decades. However, the long list of the molecules involved in the DDR and DNA repair continues to grow and the roles of the new “dots” are under intensive investigation. Here, we review the connection between DDR and DNA repair and aging and discuss the potential mechanisms by which deficient DNA repair triggers systemic effects to promote physiological or pathological aging. View Full-Text
Keywords: DNA damage response; senescence; aging DNA damage response; senescence; aging

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Pan, M.-R.; Li, K.; Lin, S.-Y.; Hung, W.-C. Connecting the Dots: From DNA Damage and Repair to Aging. Int. J. Mol. Sci. 2016, 17, 685.

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