Next Article in Journal
The Folding of de Novo Designed Protein DS119 via Molecular Dynamics Simulations
Next Article in Special Issue
Overview of Common Sleep Disorders and Intersection with Dermatologic Conditions
Previous Article in Journal
Identification and Comparative Analysis of CBS Domain-Containing Proteins in Soybean (Glycine max) and the Primary Function of GmCBS21 in Enhanced Tolerance to Low Nitrogen Stress
Previous Article in Special Issue
Peripheral Skin Temperature and Circadian Biological Clock in Shift Nurses after a Day off
Article Menu
Issue 5 (May) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2016, 17(5), 621;

Circadian Dysrhythmias, Physiological Aberrations, and the Link to Skin Cancer

School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
Department of Dermatology, University Hospitals Case Medical Center, Cleveland, OH 44106, USA
Author to whom correspondence should be addressed.
Academic Editor: Elma Baron
Received: 1 March 2016 / Revised: 11 April 2016 / Accepted: 14 April 2016 / Published: 26 April 2016
(This article belongs to the Special Issue Sleep, Circadian Rhythm and Skin)
Full-Text   |   PDF [609 KB, uploaded 26 April 2016]   |  


Circadian rhythms are core regulators of a variety of mammalian physiologic processes and oscillate in a 24-h pattern. Many peripheral organs possess endogenous rhythmicity that is then modulated by a master clock; the skin is one of these peripheral organs. The dysregulation of rhythms is associated with decreased ability to ameliorate cellular stressors at a local and global level, which then increases the propensity for the development of neoplastic growths. In this article, we review the implications of altered circadian rhythms on DNA repair as well as modified gene expression of core clock proteins with particular focus on skin models. These findings are then correlated with epidemiologic data regarding skin cancer to showcase the effects of circadian disruption on this phenomenon. View Full-Text
Keywords: circadian rhythms; skin cancer; melatonin; UVR; epidemiology circadian rhythms; skin cancer; melatonin; UVR; epidemiology

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Gutierrez, D.; Arbesman, J. Circadian Dysrhythmias, Physiological Aberrations, and the Link to Skin Cancer. Int. J. Mol. Sci. 2016, 17, 621.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top