Next Article in Journal
GL-1196 Suppresses the Proliferation and Invasion of Gastric Cancer Cells via Targeting PAK4 and Inhibiting PAK4-Mediated Signaling Pathways
Next Article in Special Issue
Campylobacter jejuni Fatal Sepsis in a Patient with Non-Hodgkin’s Lymphoma: Case Report and Literature Review of a Difficult Diagnosis
Previous Article in Journal
Induced Pluripotent Stem Cell Therapies for Cervical Spinal Cord Injury
Previous Article in Special Issue
The Impact of Specific Viruses on Clinical Outcome in Children Presenting with Acute Heart Failure
 
 
Review

Infectious Discitis and Spondylodiscitis in Children

Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Denis Girard
Int. J. Mol. Sci. 2016, 17(4), 539; https://doi.org/10.3390/ijms17040539
Received: 28 January 2016 / Revised: 18 March 2016 / Accepted: 1 April 2016 / Published: 9 April 2016
In children, infectious discitis (D) and infectious spondylodiscitis (SD) are rare diseases that can cause significant clinical problems, including spinal deformities and segmental instabilities. Moreover, when the infection spreads into the spinal channel, D and SD can cause devastating neurologic complications. Early diagnosis and treatment may reduce these risks. The main aim of this paper is to discuss recent concepts regarding the epidemiology, microbiology, clinical presentation, diagnosis, and treatment of pediatric D and SD. It is highlighted that particular attention must be paid to the identification of the causative infectious agent and its sensitivity to antibiotics, remembering that traditional culture frequently leads to negative results and modern molecular methods can significantly increase the detection rate. Several different bacterial pathogens can cause D and SD, and, in some cases, particularly those due to Staphylococcus aureus, Kingella kingae, Mycobacterium tuberculosis, Brucella spp., the appropriate choice of drug is critical to achieve cure. View Full-Text
Keywords: discitis; osteoarticular infections; pediatric orthopedics; spondylodiscitis discitis; osteoarticular infections; pediatric orthopedics; spondylodiscitis
Show Figures

Graphical abstract

MDPI and ACS Style

Principi, N.; Esposito, S. Infectious Discitis and Spondylodiscitis in Children. Int. J. Mol. Sci. 2016, 17, 539. https://doi.org/10.3390/ijms17040539

AMA Style

Principi N, Esposito S. Infectious Discitis and Spondylodiscitis in Children. International Journal of Molecular Sciences. 2016; 17(4):539. https://doi.org/10.3390/ijms17040539

Chicago/Turabian Style

Principi, Nicola, and Susanna Esposito. 2016. "Infectious Discitis and Spondylodiscitis in Children" International Journal of Molecular Sciences 17, no. 4: 539. https://doi.org/10.3390/ijms17040539

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop