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Open AccessArticle

Effects of Beverages on Alcohol Metabolism: Potential Health Benefits and Harmful Impacts

Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China
School of Chinese Medicine, The University of Hong Kong, Hong Kong 999077, China
South China Sea Bioresource Exploitation and Utilization Collaborative Innovation Center, Sun Yat-Sen University, Guangzhou 510006, China
Author to whom correspondence should be addressed.
Academic Editors: Charles Brennan and David Arráez-Román
Int. J. Mol. Sci. 2016, 17(3), 354;
Received: 23 January 2016 / Revised: 2 March 2016 / Accepted: 3 March 2016 / Published: 9 March 2016
(This article belongs to the Section Biochemistry)
PDF [396 KB, uploaded 9 March 2016]


Nonalcoholic beverages are usually consumed accompanying alcoholic drinks, and their effects on alcohol metabolism are unclear in vivo. In this study, the effects of 20 nonalcoholic beverages on alcohol metabolism and liver injury caused by alcohol were evaluated in mice. Kunming mice were orally fed with alcohol (52%, v/v) and beverages. The concentrations of ethanol and acetaldehyde in blood as well as the activities of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) in liver were assessed to indicate alcohol metabolism. The levels of aspartate aminotransferase (AST) and alanine transaminase (ALT) in serum as well as the levels of malonaldehyde (MDA) and superoxide dismutase (SOD) in liver were measured to reflect the alcohol-induced liver injury. The results showed that the treatment of soda water, green tea and honey chrysanthemum tea could accelerate ethanol metabolism and prevent liver injuries caused by alcohol when companied with excessive alcohol drinking. They might be potential dietary supplements for the alleviation of harmful effects from excessive alcohol consumption. On the contrary, some beverages such as fresh orange juice and red bull are not advised to drink when companied with alcohol consumption due to their adverse effects on ethanol induced liver injury. View Full-Text
Keywords: nonalcoholic beverages; alcohol metabolism; hepatoprotection; harmful impact nonalcoholic beverages; alcohol metabolism; hepatoprotection; harmful impact

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Wang, F.; Zhang, Y.-J.; Zhou, Y.; Li, Y.; Zhou, T.; Zheng, J.; Zhang, J.-J.; Li, S.; Xu, D.-P.; Li, H.-B. Effects of Beverages on Alcohol Metabolism: Potential Health Benefits and Harmful Impacts. Int. J. Mol. Sci. 2016, 17, 354.

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