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Int. J. Mol. Sci. 2016, 17(10), 1697;

Gelation Behaviors and Mechanism of Silk Fibroin According to the Addition of Nitrate Salts

Department of Advanced Organic Materials and Textile System Engineering, Chungnam National University, Daejeon 34134, Korea
Authors to whom correspondence should be addressed.
Academic Editors: John G. Hardy and Chris Holland
Received: 10 August 2016 / Revised: 8 September 2016 / Accepted: 28 September 2016 / Published: 10 October 2016
(This article belongs to the Special Issue Silk-Based Materials: From Production to Characterization)
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Silk fibroin (SF) is a typical fibrous protein that is secreted by silkworms and spiders. It has been used in a variety of areas, and especially for tissue-engineering scaffolds, due to its sound processability, mechanical properties, biodegradability, and biocompatibility. With respect to gelation, the SF gelation time is long in aqueous solutions, so a novel approach is needed to shorten this time. The solubility of regenerated SF is sound in formic acid (FA), which is a carboxylic acid of the simplest structure. In this study, SF was dissolved in formic acid, and the addition of salts then induced a rapid gelation that accompanied a solution-color change. Based on the gelation behaviors of the SF solution according to different SF and salt concentrations, the gelation mechanism was investigated. View Full-Text
Keywords: silk fibroin; gelation; nitration; tyrosine silk fibroin; gelation; nitration; tyrosine

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Im, D.S.; Kim, M.H.; Yoon, Y.I.; Park, W.H. Gelation Behaviors and Mechanism of Silk Fibroin According to the Addition of Nitrate Salts. Int. J. Mol. Sci. 2016, 17, 1697.

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