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Enzymatic Kinetic Resolution of 2-Piperidineethanol for the Enantioselective Targeted and Diversity Oriented Synthesis

Dipartimento di Chimica, Universita degli Studi di Milano, Via Golgi 19, 20133 Milano, Italy
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Authors to whom correspondence should be addressed.
This paper is dedicated to the memory of Bruno Danieli, Professor of Organic Chemistry, Università degli Studi di Milano, 20122 Milano, Italy.
Academic Editor: Vladimír Křen
Int. J. Mol. Sci. 2016, 17(1), 17; https://doi.org/10.3390/ijms17010017
Received: 2 November 2015 / Revised: 11 December 2015 / Accepted: 15 December 2015 / Published: 24 December 2015
(This article belongs to the Special Issue Molecular Biocatalysis)
2-Piperidineethanol (1) and its corresponding N-protected aldehyde (2) were used for the synthesis of several natural and synthetic compounds. The existence of a stereocenter at position 2 of the piperidine skeleton and the presence of an easily-functionalized group, such as the alcohol, set 1 as a valuable starting material for enantioselective synthesis. Herein, are presented both synthetic and enzymatic methods for the resolution of the racemic 1, as well as an overview of synthesized natural products starting from the enantiopure 1. View Full-Text
Keywords: 2-piperidineethanol; piperidine alkaloids; enzymatic resolution; alkaloid synthesis 2-piperidineethanol; piperidine alkaloids; enzymatic resolution; alkaloid synthesis
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Perdicchia, D.; Christodoulou, M.S.; Fumagalli, G.; Calogero, F.; Marucci, C.; Passarella, D. Enzymatic Kinetic Resolution of 2-Piperidineethanol for the Enantioselective Targeted and Diversity Oriented Synthesis. Int. J. Mol. Sci. 2016, 17, 17.

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