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Iron in Multiple Sclerosis and Its Noninvasive Imaging with Quantitative Susceptibility Mapping

Department of Radiology, Weill Cornell Medical College, New York, NY 10044, USA
Department of Neurology, Yale School of Medicine, Yale University, New Haven, CT 06511, USA
Department of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA
Author to whom correspondence should be addressed.
Academic Editors: Christoph Kleinschnitz and Sven Meuth
Int. J. Mol. Sci. 2016, 17(1), 100;
Received: 29 May 2015 / Revised: 5 January 2016 / Accepted: 7 January 2016 / Published: 14 January 2016
(This article belongs to the Special Issue Advances in Multiple Sclerosis)
PDF [5686 KB, uploaded 14 January 2016]


Iron is considered to play a key role in the development and progression of Multiple Sclerosis (MS). In particular, iron that accumulates in myeloid cells after the blood-brain barrier (BBB) seals may contribute to chronic inflammation, oxidative stress and eventually neurodegeneration. Magnetic resonance imaging (MRI) is a well-established tool for the non-invasive study of MS. In recent years, an advanced MRI method, quantitative susceptibility mapping (QSM), has made it possible to study brain iron through in vivo imaging. Moreover, immunohistochemical investigations have helped defining the lesional and cellular distribution of iron in MS brain tissue. Imaging studies in MS patients and of brain tissue combined with histological studies have provided important insights into the role of iron in inflammation and neurodegeneration in MS. View Full-Text
Keywords: MS lesion; quantitative susceptibility mapping (QSM); deep grey matter (DGM); MRI MS lesion; quantitative susceptibility mapping (QSM); deep grey matter (DGM); MRI

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Stüber, C.; Pitt, D.; Wang, Y. Iron in Multiple Sclerosis and Its Noninvasive Imaging with Quantitative Susceptibility Mapping. Int. J. Mol. Sci. 2016, 17, 100.

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