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Int. J. Mol. Sci. 2015, 16(9), 21070-21086;

Preparation and Characterization of Lanthanum-Incorporated Hydroxyapatite Coatings on Titanium Substrates

1,* , 1,* and 4
School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325027, China
Department of Prosthetic Dentistry, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310006, China
Department of Prosthetic Dentistry, College of Stomatology, Ningxia Medical University, Yinchuan 750004, China
Department of Oral Implantology and Prosthetic Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), Research Institute MOVE, VU University and University of Amsterdam, Amsterdam 1081 HV, The Netherlands
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Academic Editor: Mohamed N. Rahaman
Received: 2 June 2015 / Revised: 24 August 2015 / Accepted: 25 August 2015 / Published: 2 September 2015
(This article belongs to the Section Materials Science)
Full-Text   |   PDF [3113 KB, uploaded 2 September 2015]   |  


Titanium (Ti) has been widely used in clinical applications for its excellent biocompatibility and mechanical properties. However, the bioinertness of the surface of Ti has motivated researchers to improve the physicochemical and biological properties of the implants through various surface modifications, such as coatings. For this purpose, we prepared a novel bioactive material, a lanthanum-incorporated hydroxyapatite (La-HA) coating, using a dip-coating technique with a La-HA sol along with post-heat treatment. The XRD, FTIR and EDX results presented in this paper confirmed that lanthanum was successfully incorporated into the structure of HA. The La-HA coating was composed of rod-like particles which densely compacted together without microcracks. The results of the interfacial shear strength test indicated that the incorporation of lanthanum increased the bonding strength of the HA coating. The mass loss ratios under acidic conditions (pH = 5.5) suggested that the La-HA coatings have better acid resistance. The cytocompatibility of the La-HA coating was also revealed by the relative activity of alkaline phosphatase, cellular morphology and cell proliferation assay in vitro. The present study suggested that La-HA coated on Ti has promising potential for applications in the development of a new type of bioactive coating for metal implants. View Full-Text
Keywords: hydroxyapatite; lanthanum; sol-gel; coating; degradation hydroxyapatite; lanthanum; sol-gel; coating; degradation

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Lou, W.; Dong, Y.; Zhang, H.; Jin, Y.; Hu, X.; Ma, J.; Liu, J.; Wu, G. Preparation and Characterization of Lanthanum-Incorporated Hydroxyapatite Coatings on Titanium Substrates. Int. J. Mol. Sci. 2015, 16, 21070-21086.

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