Next Article in Journal
Glucagon Like Peptide-1 (GLP-1) Modulates OVA-Induced Airway Inflammation and Mucus Secretion Involving a Protein Kinase A (PKA)-Dependent Nuclear Factor-κB (NF-κB) Signaling Pathway in Mice
Next Article in Special Issue
Supracolloidal Assemblies as Sacrificial Templates for Porous Silk-Based Biomaterials
Previous Article in Journal
Impact of Single Nucleotide Polymorphisms (SNPs) on Immunosuppressive Therapy in Lung Transplantation
Previous Article in Special Issue
Resolving Intra- and Inter-Molecular Structure with Non-Contact Atomic Force Microscopy
Article

Perfluoroalkyl-Functionalized Hyperbranched Polyglycerol as Pore Forming Agents and Supramolecular Hosts in Polymer Microspheres

1
Institute for Chemistry and Biochemistry, Freie Universität Berlin, Takustrasse 3, Berlin 14195, Germany
2
School of Engineering and Applied Sciences, Harvard University, 29 Oxford St., Cambridge, MA 02138, USA
3
Department of Physics, Harvard University, 29 Oxford St., Cambridge, MA 02138, USA
*
Author to whom correspondence should be addressed.
Academic Editor: John Hardy
Int. J. Mol. Sci. 2015, 16(9), 20183-20194; https://doi.org/10.3390/ijms160920183
Received: 30 June 2015 / Revised: 22 July 2015 / Accepted: 17 August 2015 / Published: 26 August 2015
(This article belongs to the Special Issue Supramolecular Interactions)
Perfluoroalkyl-functionalized, hyperbranched polyglycerols that produce stable microbubbles are integrated into a microfluidic emulsion to create porous microspheres. In a previously-presented work a dendrimer with a perfluorinated shell was used. By replacing this dendrimer core with a hyperbranched core and evaluating different core sizes and degrees of fluorinated shell functionalization, we optimized the process to a more convenient synthesis and higher porosities. The new hyperbranched polyglycerol porogens produced more pores and can be used to prepare microspheres with porosity up to 12% (v/v). The presented preparation forms pores with a perfluoroalkyl-functionalized surface that enables the resulting microspheres to act as supramolecular host systems. The microspheres can incorporate gases into the pores and actives in the polymer matrix, while the perfluoroalkylated pore surface can be used to immobilize perfluoro-tagged molecules onto the pores by fluorous-fluorous interaction. View Full-Text
Keywords: polyglycerol; non-covalent; fluorous; supramolecular; microbubbles; microfluidics; porous; template; functional; host-guest system polyglycerol; non-covalent; fluorous; supramolecular; microbubbles; microfluidics; porous; template; functional; host-guest system
Show Figures

Graphical abstract

MDPI and ACS Style

Wagner, O.; Zieringer, M.; Duncanson, W.J.; Weitz, D.A.; Haag, R. Perfluoroalkyl-Functionalized Hyperbranched Polyglycerol as Pore Forming Agents and Supramolecular Hosts in Polymer Microspheres. Int. J. Mol. Sci. 2015, 16, 20183-20194. https://doi.org/10.3390/ijms160920183

AMA Style

Wagner O, Zieringer M, Duncanson WJ, Weitz DA, Haag R. Perfluoroalkyl-Functionalized Hyperbranched Polyglycerol as Pore Forming Agents and Supramolecular Hosts in Polymer Microspheres. International Journal of Molecular Sciences. 2015; 16(9):20183-20194. https://doi.org/10.3390/ijms160920183

Chicago/Turabian Style

Wagner, Olaf, Maximilian Zieringer, Wynter J. Duncanson, David A. Weitz, and Rainer Haag. 2015. "Perfluoroalkyl-Functionalized Hyperbranched Polyglycerol as Pore Forming Agents and Supramolecular Hosts in Polymer Microspheres" International Journal of Molecular Sciences 16, no. 9: 20183-20194. https://doi.org/10.3390/ijms160920183

Find Other Styles

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop