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Int. J. Mol. Sci. 2015, 16(8), 18732-18740;

LincRNA-p21: Implications in Human Diseases

Institute of Aging Research, Guangdong Medical University, Dongguan 523808, China
Institute of Biochemistry & Molecular Biology, Guangdong Medical University, Zhanjiang 524023, China
Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Guangdong Medical University, Dongguan 523808, China
Institute of Laboratory Medicine, Guangdong Medical University, Dongguan 523808, China
Department of Pharmacology and the Penn State Hershey Cancer Institute, Milton S. Hershey Medical Center, the Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Author to whom correspondence should be addressed.
Academic Editor: Martin Pichler
Received: 4 July 2015 / Revised: 4 July 2015 / Accepted: 4 August 2015 / Published: 11 August 2015
(This article belongs to the Collection Regulation by Non-Coding RNAs)
Full-Text   |   PDF [979 KB, uploaded 11 August 2015]   |  


Long noncoding RNAs (lncRNAs), which lack significant protein-coding capacity, regulate various biological processes through diverse and as yet poorly understood molecular mechanisms. However, a number of studies in the past few years have documented important functions for lncRNAs in human diseases. Among these lncRNAs, lincRNA-p21 has been proposed to be a novel regulator of cell proliferation, apoptosis and DNA damage response, and involved in the initiation and progression of human diseases. In this review, we summarize the current knowledge of lincRNA-p21, mainly focus on the known biological functions and its underlying mechanisms. Moreover, we highlight the growing body of evidences for the importance of lincRNA-p21 in diverse human diseases, which indicate lincRNA-p21 as a potential diagnostic marker and/or a valuable therapeutic target for these diseases. View Full-Text
Keywords: long non-coding RNA; lincRNA-p21; gene regulation; diseases long non-coding RNA; lincRNA-p21; gene regulation; diseases

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Tang, S.-S.; Zheng, B.-Y.; Xiong, X.-D. LincRNA-p21: Implications in Human Diseases. Int. J. Mol. Sci. 2015, 16, 18732-18740.

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