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Int. J. Mol. Sci. 2015, 16(7), 14640-14654;

Metacognition in Early Phase Psychosis: Toward Understanding Neural Substrates

Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Prevention and Recovery Center for Early Psychosis, Midtown Community Mental Health Centers, Eskenazi Hospital, Indianapolis, IN 46202, USA
Department of Psychiatry, Roudebush VA Medical Center, Indianapolis, IN 46202, USA
Author to whom correspondence should be addressed.
Academic Editor: Kenji Hashimoto
Received: 8 May 2015 / Revised: 10 June 2015 / Accepted: 23 June 2015 / Published: 29 June 2015
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Individuals in the early phases of psychotic illness have disturbed metacognitive capacity, which has been linked to a number of poor outcomes. Little is known, however, about the neural systems associated with metacognition in this population. The purpose of this study was to elucidate the neuroanatomical correlates of metacognition. We anticipated that higher levels of metacognition may be dependent upon gray matter density (GMD) of regions within the prefrontal cortex. Examining whole-brain structure in 25 individuals with early phase psychosis, we found positive correlations between increased medial prefrontal cortex and ventral striatum GMD and higher metacognition. These findings represent an important step in understanding the path through which the biological correlates of psychotic illness may culminate into poor metacognition and, ultimately, disrupted functioning. Such a path will serve to validate and promote metacognition as a viable treatment target in early phase psychosis. View Full-Text
Keywords: early psychosis; schizophrenia; metacognition; brain; magnetic resonance imaging early psychosis; schizophrenia; metacognition; brain; magnetic resonance imaging

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Vohs, J.L.; Hummer, T.A.; Yung, M.G.; Francis, M.M.; Lysaker, P.H.; Breier, A. Metacognition in Early Phase Psychosis: Toward Understanding Neural Substrates. Int. J. Mol. Sci. 2015, 16, 14640-14654.

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