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Int. J. Mol. Sci. 2015, 16(5), 10324-10336;

Cell Adhesion and in Vivo Osseointegration of Sandblasted/Acid Etched/Anodized Dental Implants

Department of Prosthodontics, Dental Research Institute, Biomedical Research Institute, School of Dentistry, Pusan National University, Yangsan 676-870, Korea
Division of Bioimaging, Chuncheon Center, Korea Basic Science Institute, Gangwon-do 200-701, Korea
Research Development Institute, Cowellmedi Co., Ltd., Busan 617-801, Korea
Department of Veterinary Surgery, College of Veterinary Medicine, Chonnam National University, Gwangju 500-757, Korea
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Mohamed N. Rahaman
Received: 25 March 2015 / Revised: 8 April 2015 / Accepted: 29 April 2015 / Published: 6 May 2015
(This article belongs to the Special Issue Biomaterials for Tissue Engineering)
Full-Text   |   PDF [7861 KB, uploaded 6 May 2015]   |  


The authors describe a new type of titanium (Ti) implant as a Modi-anodized (ANO) Ti implant, the surface of which was treated by sandblasting, acid etching (SLA), and anodized techniques. The aim of the present study was to evaluate the adhesion of MG-63 cells to Modi-ANO surface treated Ti in vitro and to investigate its osseointegration characteristics in vivo. Four different types of Ti implants were examined, that is, machined Ti (control), SLA, anodized, and Modi-ANO Ti. In the cell adhesion study, Modi-ANO Ti showed higher initial MG-63 cell adhesion and induced greater filopodia growth than other groups. In vivo study in a beagle model revealed the bone-to-implant contact (BIC) of Modi-ANO Ti (74.20% ± 10.89%) was much greater than those of machined (33.58% ± 8.63%), SLA (58.47% ± 12.89), or ANO Ti (59.62% ± 18.30%). In conclusion, this study demonstrates that Modi-ANO Ti implants produced by sandblasting, acid etching, and anodizing improve cell adhesion and bone ongrowth as compared with machined, SLA, or ANO Ti implants. These findings suggest that the application of Modi-ANO surface treatment could improve the osseointegration of dental implant. View Full-Text
Keywords: titanium implant; sandblasting and acid etching; anodization; osteoblast; osseointegration titanium implant; sandblasting and acid etching; anodization; osteoblast; osseointegration

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Kim, M.-H.; Park, K.; Choi, K.-H.; Kim, S.-H.; Kim, S.E.; Jeong, C.-M.; Huh, J.-B. Cell Adhesion and in Vivo Osseointegration of Sandblasted/Acid Etched/Anodized Dental Implants. Int. J. Mol. Sci. 2015, 16, 10324-10336.

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