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Int. J. Mol. Sci. 2015, 16(5), 10095-10104;

Histomorphometric Evaluation of the Small Coronary Arteries in Rats Exposed to Industrial Noise

Center for Interdisciplinary Research Egas Moniz (CIIEM), Health Sciences Institute, 2829-511 Monte de Caparica, Portugal
Department of Anatomy, Abel Salazar Biomedical Sciences Institute, University of Porto, 4050-313 Porto, Portugal
Author to whom correspondence should be addressed.
Academic Editor: Francis J. Miller
Received: 30 January 2015 / Revised: 2 April 2015 / Accepted: 14 April 2015 / Published: 4 May 2015
(This article belongs to the Section Biochemistry)
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Morphological changes induced by industrial noise (IN) have been experimentally observed in several organs. Histological observations of the coronary arteries showed prominent perivascular tissue and fibrosis among IN-exposed rats. The effects on the small arteries are unknown. Objective: To evaluate the histomorphometric changes induced by IN on rat heart small arteries. Methods: Twenty Wistar rats exposed to IN during a maximum period of seven months and 20 age-matched controls were studied. Hearts were transversely sectioned from ventricular apex to atria and a mid-ventricular fragment was selected for analysis. The histological images were obtained with an optical microscope using 400× magnifications. A total of 634 arterial vessels (298 IN-exposed and 336 controls) were selected. The mean lumen-to-vessel wall (L/W) and mean vessel wall-to-perivascular tissue (W/P) ratios were calculated using image J software. Results: There were no differences between exposed and control animals in their L/W ratios (p = 0.687) and time variations in this ratio were non-significant (p = 0.110). In contrast, exposed animals showed lower W/P ratios than control animals (p < 0.001), with significant time variations (p = 0.004). Conclusions: Industrial noise induced an increase in the perivascular tissue of rat small coronary arteries, with significant development of periarterial fibrosis. View Full-Text
Keywords: industrial noise; small coronary arteries; low-frequency noise industrial noise; small coronary arteries; low-frequency noise

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Lousinha, A.; Antunes, E.; Borrecho, G.; Oliveira, M.J.; Brito, J.; Santos, J.M. Histomorphometric Evaluation of the Small Coronary Arteries in Rats Exposed to Industrial Noise. Int. J. Mol. Sci. 2015, 16, 10095-10104.

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