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Male Reproductive Cancers and Infertility: A Mutual Relationship

Center for Reproductive Medicine, Cleveland Clinic, Mail Code X-11, 10681 Carnegie Avenue, Cleveland, OH 44195, USA
Department of Animal Physiology, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture, Tr. A. Hlinku 2, 94976 Nitra, Slovakia
College of Medicine, Alfaisal University, P.O. Box 50927, 11533 Riyadh, Saudi Arabia
Author to whom correspondence should be addressed.
Academic Editor: Robert J. Norman
Int. J. Mol. Sci. 2015, 16(4), 7230-7260;
Received: 18 February 2015 / Revised: 29 March 2015 / Accepted: 29 March 2015 / Published: 31 March 2015
(This article belongs to the Special Issue Advances in Reproductive Biology)
Reproductive dysfunction and malignancies related to the male gender represent a serious health concern, whose incidence has significantly risen over the past years. Prior to treatment, testicular or prostate cancer patients often display poor semen characteristics similar to subfertile or infertile patients. This fact is underscored by cases where the malignancy is often diagnosed in males who undergo a general fertility screening. This review aims to examine the associations between male infertility and reproductive cancers focusing on common etiologies and biological mechanisms underlining these pathologies. Furthermore, we discuss compelling epidemiological data hypothesizing that male reproductive failure may act as a precursor of future andrological malignancies, including testicular or prostate cancer, thus providing a stimulus for a more specific research in male reproductive health and emphasizing the importance of this relation for physicians taking care of male patients with a reproductive disease. View Full-Text
Keywords: male infertility; testicular cancer; prostate cancer; genetics; epigenetics; environment; fetal environment; relationships male infertility; testicular cancer; prostate cancer; genetics; epigenetics; environment; fetal environment; relationships
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Tvrda, E.; Agarwal, A.; Alkuhaimi, N. Male Reproductive Cancers and Infertility: A Mutual Relationship. Int. J. Mol. Sci. 2015, 16, 7230-7260.

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