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Int. J. Mol. Sci. 2015, 16(4), 7173-7194;

Interaction of tRNA with Eukaryotic Ribosome

Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, pr. Lavrentieva, 8, 630090 Novosibirsk, Russia
Department of Natural Sciences, Novosibirsk State University, ul. Pirogova, 2, 630090 Novosibirsk, Russia
Author to whom correspondence should be addressed.
Academic Editor: Michael Ibba
Received: 8 December 2014 / Revised: 20 March 2015 / Accepted: 23 March 2015 / Published: 30 March 2015
(This article belongs to the Special Issue Functions of Transfer RNAs)
PDF [3742 KB, uploaded 30 March 2015]


This paper is a review of currently available data concerning interactions of tRNAs with the eukaryotic ribosome at various stages of translation. These data include the results obtained by means of cryo-electron microscopy and X-ray crystallography applied to various model ribosomal complexes, site-directed cross-linking with the use of tRNA derivatives bearing chemically or photochemically reactive groups in the CCA-terminal fragment and chemical probing of 28S rRNA in the region of the peptidyl transferase center. Similarities and differences in the interactions of tRNAs with prokaryotic and eukaryotic ribosomes are discussed with concomitant consideration of the extent of resemblance between molecular mechanisms of translation in eukaryotes and bacteria. View Full-Text
Keywords: tRNA; eukaryotic ribosome; eukaryotic translation factors; ribosomal RNA; ribosomal proteins; classical and hybrid tRNA states tRNA; eukaryotic ribosome; eukaryotic translation factors; ribosomal RNA; ribosomal proteins; classical and hybrid tRNA states

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Graifer, D.; Karpova, G. Interaction of tRNA with Eukaryotic Ribosome. Int. J. Mol. Sci. 2015, 16, 7173-7194.

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