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Int. J. Mol. Sci. 2015, 16(3), 6571-6594;

Aminoacyl-tRNA Synthetase Complexes in Evolution

Laboratoire d'Enzymologie et Biochimie Structurales (LEBS), CNRS, Université Paris-Sud, 1 avenue de la Terrasse, 91190 Gif-sur-Yvette, France
Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Université Paris-Sud, 1 avenue de la Terrasse, 91190 Gif-sur-Yvette, France
Present address: Institut Curie, CNRS UMR 168, Université Pierre et Marie Curie, 75248 Paris, France
Author to whom correspondence should be addressed.
Academic Editor: Michael Ibba
Received: 15 December 2014 / Revised: 17 February 2015 / Accepted: 11 March 2015 / Published: 23 March 2015
(This article belongs to the Special Issue Functions of Transfer RNAs)
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Aminoacyl-tRNA synthetases are essential enzymes for interpreting the genetic code. They are responsible for the proper pairing of codons on mRNA with amino acids. In addition to this canonical, translational function, they are also involved in the control of many cellular pathways essential for the maintenance of cellular homeostasis. Association of several of these enzymes within supramolecular assemblies is a key feature of organization of the translation apparatus in eukaryotes. It could be a means to control their oscillation between translational functions, when associated within a multi-aminoacyl-tRNA synthetase complex (MARS), and nontranslational functions, after dissociation from the MARS and association with other partners. In this review, we summarize the composition of the different MARS described from archaea to mammals, the mode of assembly of these complexes, and their roles in maintenance of cellular homeostasis. View Full-Text
Keywords: multi-aminoacyl-tRNA synthetase complexes; supramolecular assemblies; evolution; function multi-aminoacyl-tRNA synthetase complexes; supramolecular assemblies; evolution; function

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Havrylenko, S.; Mirande, M. Aminoacyl-tRNA Synthetase Complexes in Evolution. Int. J. Mol. Sci. 2015, 16, 6571-6594.

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