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Int. J. Mol. Sci. 2015, 16(3), 6353-6372;

The Role of Hypoxia-Induced miR-210 in Cancer Progression

Department of Biological Sciences, University of the Sciences, 600 S. 43rd Str., Philadelphia, PA 19104, USA
Author to whom correspondence should be addressed.
Academic Editor: Alan C. Leonard
Received: 21 January 2015 / Revised: 11 March 2015 / Accepted: 12 March 2015 / Published: 19 March 2015
(This article belongs to the Special Issue Molecular Machinery of Cell Growth Regulation)
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Prolonged hypoxia, the event of insufficient oxygen, is known to upregulate tumor development and growth by promoting the formation of a neoplastic environment. The recent discovery that a subset of cellular microRNAs (miRs) are upregulated during hypoxia, where they function to promote tumor development, highlights the importance of hypoxia-induced miRs as targets for continued investigation. miRs are short, non-coding transcripts involved in gene expression and regulation. Under hypoxic conditions, miR-210 becomes highly upregulated in response to hypoxia inducing factors (HIFs). HIF-1α drives miR-210’s overexpression and the resultant alteration of cellular processes, including cell cycle regulation, mitochondria function, apoptosis, angiogenesis and metastasis. Here we discuss hypoxia-induced dysregulation of miR-210 and the resultant changes in miR-210 protein targets that regulate cancer progression. Potential methods of targeting miR-210 as a therapeutic tool are also explored. View Full-Text
Keywords: miR-210; hypoxia; microRNA; apoptosis; angiogenesis; cancer miR-210; hypoxia; microRNA; apoptosis; angiogenesis; cancer

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Dang, K.; Myers, K.A. The Role of Hypoxia-Induced miR-210 in Cancer Progression. Int. J. Mol. Sci. 2015, 16, 6353-6372.

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