Next Article in Journal
De Novo Transcriptome Sequencing Analysis of cDNA Library and Large-Scale Unigene Assembly in Japanese Red Pine (Pinus densiflora)
Next Article in Special Issue
Ischemia, Immunosuppression and Infection—Tackling the Predicaments of Post-Stroke Complications
Previous Article in Journal / Special Issue
The Role of the Neuroprotective Factor Npas4 in Cerebral Ischemia
Article Menu
Issue 12 (December) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2015, 16(12), 29029-29046;

Innate Immunity and Inflammation Post-Stroke: An α7-Nicotinic Agonist Perspective

Department of Pathology, University of Otago, Dunedin 9054, New Zealand
Department of Anatomy, Brain Health Research Centre and Brain Research New Zealand, University of Otago, P.O. Box 913, Dunedin 9054, New Zealand
Faculty of Pharmacy, The University of Sydney, Sydney, NSW 2006, Australia
Author to whom correspondence should be addressed.
Academic Editors: Chris Sobey and Hyun Ah Kim
Received: 14 October 2015 / Revised: 24 November 2015 / Accepted: 25 November 2015 / Published: 4 December 2015
(This article belongs to the Special Issue The Immune System and Inflammation in Cerebral Ischemia)
Full-Text   |   PDF [1370 KB, uploaded 4 December 2015]   |  


Stroke is one of the leading causes of death and long-term disability, with limited treatment options available. Inflammation contributes to damage tissue in the central nervous system across a broad range of neuropathologies, including Alzheimer’s disease, pain, Schizophrenia, and stroke. While the immune system plays an important role in contributing to brain damage produced by ischemia, the damaged brain, in turn, can exert a powerful immune-suppressive effect that promotes infections and threatens the survival of stroke patients. Recently the cholinergic anti-inflammatory pathway, in particular its modulation using α7-nicotinic acetylcholine receptor (α7-nAChR) ligands, has shown potential as a strategy to dampen the inflammatory response and facilitate functional recovery in stroke patients. Here we discuss the current literature on stroke-induced inflammation and the effects of α7-nAChR modulators on innate immune cells. View Full-Text
Keywords: stroke; inflammation; nicotinic; nicotinic acetylcholine receptor agonist; immune response; myeloid cells stroke; inflammation; nicotinic; nicotinic acetylcholine receptor agonist; immune response; myeloid cells

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Neumann, S.; Shields, N.J.; Balle, T.; Chebib, M.; Clarkson, A.N. Innate Immunity and Inflammation Post-Stroke: An α7-Nicotinic Agonist Perspective. Int. J. Mol. Sci. 2015, 16, 29029-29046.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top