Next Article in Journal
Application of Green Tea Catechin for Inducing the Osteogenic Differentiation of Human Dedifferentiated Fat Cells in Vitro
Next Article in Special Issue
The Safety Evaluation of Salvianolic Acid B and Ginsenoside Rg1 Combination on Mice
Previous Article in Journal
Effects of Monotypic and Binary Mixtures of Metal Oxide Nanoparticles on Microbial Growth in Sandy Soil Collected from Artificial Recharge Sites
Previous Article in Special Issue
Andrographolide Inhibits Ovariectomy-Induced Bone Loss via the Suppression of RANKL Signaling Pathways
Article Menu
Issue 11 (November) cover image

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2015, 16(11), 27978-27987;

Henrin A: A New Anti-HIV Ent-Kaurane Diterpene from Pteris henryi

Guiyang College of Traditional Chinese Medicine, Guiyang 550002, China
School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Kowloon, Hong Kong, China
School of Public Health, Jilin University, Changchun 130021, China
Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Academic Editor: Ge Zhang
Received: 17 September 2015 / Revised: 26 October 2015 / Accepted: 13 November 2015 / Published: 24 November 2015
Full-Text   |   PDF [2331 KB, uploaded 24 November 2015]   |  


Henrin A (1), a new ent-kaurane diterpene, was isolated from the leaves of Pteris henryi. The chemical structure was elucidated by analysis of the spectroscopic data including one-dimensional (1D) and two-dimensional (2D) NMR spectra, and was further confirmed by X-ray crystallographic analysis. The compound was evaluated for its biological activities against a panel of cancer cell lines, dental bacterial biofilm formation, and HIV. It displayed anti-HIV potential with an IC50 value of 9.1 µM (SI = 12.2). View Full-Text
Keywords: Pteris henryi; ent-kaurane diterpene; henrin A; bioactivity evaluation; anti-HIV activity Pteris henryi; ent-kaurane diterpene; henrin A; bioactivity evaluation; anti-HIV activity

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Li, W.-F.; Wang, J.; Zhang, J.-J.; Song, X.; Ku, C.-F.; Zou, J.; Li, J.-X.; Rong, L.-J.; Pan, L.-T.; Zhang, H.-J. Henrin A: A New Anti-HIV Ent-Kaurane Diterpene from Pteris henryi. Int. J. Mol. Sci. 2015, 16, 27978-27987.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top