Next Article in Journal
Protein Recognition in Drug-Induced DNA Alkylation: When the Moonlight Protein GAPDH Meets S23906-1/DNA Minor Groove Adducts
Next Article in Special Issue
Effect of Human Adipose Tissue Mesenchymal Stem Cells on the Regeneration of Ovine Articular Cartilage
Previous Article in Journal
Validation of PDE9A Gene Identified in GWAS Showing Strong Association with Milk Production Traits in Chinese Holstein
Previous Article in Special Issue
The Functions of BMP3 in Rabbit Articular Cartilage Repair
Article Menu
Issue 11 (November) cover image

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2015, 16(11), 26543-26554;

Posterior Wnts Have Distinct Roles in Specification and Patterning of the Planarian Posterior Region

Department of Genetics and Institute of Biomedicine, University of Barcelona, Barcelona E-08028, Catalonia, Spain
Author to whom correspondence should be addressed.
Academic Editor: Francesc Cebrià
Received: 20 September 2015 / Revised: 26 October 2015 / Accepted: 28 October 2015 / Published: 5 November 2015
(This article belongs to the Special Issue Molecular and Cellular Basis of Regeneration and Tissue Repair)
Full-Text   |   PDF [10452 KB, uploaded 5 November 2015]   |  


The wnt signaling pathway is an intercellular communication mechanism essential in cell-fate specification, tissue patterning and regional-identity specification. A βcatenin-dependent signal specifies the AP (Anteroposterior) axis of planarians, both during regeneration of new tissues and during normal homeostasis. Accordingly, four wnts (posterior wnts) are expressed in a nested manner in central and posterior regions of planarians. We have analyzed the specific role of each posterior wnt and the possible cooperation between them in specifying and patterning planarian central and posterior regions. We show that each posterior wnt exerts a distinct role during re-specification and maintenance of the central and posterior planarian regions, and that the integration of the different wnt signals (βcatenin dependent and independent) underlies the patterning of the AP axis from the central region to the tip of the tail. Based on these findings and data from the literature, we propose a model for patterning the planarian AP axis. View Full-Text
Keywords: patterning; identity specification; wnt signaling; planarians patterning; identity specification; wnt signaling; planarians

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Sureda-Gómez, M.; Pascual-Carreras, E.; Adell, T. Posterior Wnts Have Distinct Roles in Specification and Patterning of the Planarian Posterior Region. Int. J. Mol. Sci. 2015, 16, 26543-26554.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top