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Multi-Functional Macromers for Hydrogel Design in Biomedical Engineering and Regenerative Medicine

Institute of Pharmacy, Pharmaceutical Technology, Leipzig University, Eilenburger Str. 15a, D-04317 Leipzig, Germany
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Academic Editor: Aaron Tan
Int. J. Mol. Sci. 2015, 16(11), 27677-27706; https://doi.org/10.3390/ijms161126056
Received: 9 October 2015 / Revised: 31 October 2015 / Accepted: 4 November 2015 / Published: 19 November 2015
(This article belongs to the Special Issue Artificial Organs)
Contemporary biomaterials are expected to provide tailored mechanical, biological and structural cues to encapsulated or invading cells in regenerative applications. In addition, the degradative properties of the material also have to be adjustable to the desired application. Oligo- or polymeric building blocks that can be further cross-linked into hydrogel networks, here addressed as macromers, appear as the prime option to assemble gels with the necessary degrees of freedom in the adjustment of the mentioned key parameters. Recent developments in the design of multi-functional macromers with two or more chemically different types of functionalities are summarized and discussed in this review illustrating recent trends in the development of advanced hydrogel building blocks for regenerative applications. View Full-Text
Keywords: functional groups; chemical cross-linking; physical gelation; macromer; macromonomer; smart hydrogel; N-isopropylacrylamide; copolymer; click chemistry functional groups; chemical cross-linking; physical gelation; macromer; macromonomer; smart hydrogel; N-isopropylacrylamide; copolymer; click chemistry
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MDPI and ACS Style

Hacker, M.C.; Nawaz, H.A. Multi-Functional Macromers for Hydrogel Design in Biomedical Engineering and Regenerative Medicine. Int. J. Mol. Sci. 2015, 16, 27677-27706. https://doi.org/10.3390/ijms161126056

AMA Style

Hacker MC, Nawaz HA. Multi-Functional Macromers for Hydrogel Design in Biomedical Engineering and Regenerative Medicine. International Journal of Molecular Sciences. 2015; 16(11):27677-27706. https://doi.org/10.3390/ijms161126056

Chicago/Turabian Style

Hacker, Michael C., and Hafiz A. Nawaz 2015. "Multi-Functional Macromers for Hydrogel Design in Biomedical Engineering and Regenerative Medicine" International Journal of Molecular Sciences 16, no. 11: 27677-27706. https://doi.org/10.3390/ijms161126056

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