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The in Vitro Antimicrobial Efficacy of PDT against Periodontopathogenic Bacteria

Private Practice, Zahnarztpraxis an der Murg, Metzgerstrasse 1, Frauenfeld CH 8500, Switzerland
Center of Dental Medicine, Clinic of Preventive Dentistry, Periodontology and Cariology, University of Zurich, Plattenstrasse 11, Zürich CH 8032, Switzerland
Author to whom correspondence should be addressed.
Academic Editors: Michael R. Hamblin and Ying-ying Huang
Int. J. Mol. Sci. 2015, 16(11), 27327-27338;
Received: 29 July 2015 / Revised: 28 September 2015 / Accepted: 3 November 2015 / Published: 13 November 2015
(This article belongs to the Special Issue Advances in Photodynamic Therapy)
Periodontitis, an inflammatory disease, is caused by biofilms with a mixed microbial etiology and involves the progressive destruction of the tooth-supporting tissues. A rising number of studies investigate the clinical potential of photodynamic therapy (PDT) as an adjunct during active therapy. The aim of the present review was to evaluate the available literature for the in vitro antimicrobial efficacy of photodynamic therapy focusing on the periodontopathogenic bacteria Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis and Fusobacterium nucleatum. The focused question was: “Is it possible to decrease (at least 3 log steps or 99.9%) or even eliminate bacterial growth by photodynamic therapy in vitro when compared to untreated control groups or control groups treated by placebo?” In general, PDT resulted in a substantial reduction of surviving bacteria. However, not all studies showed the desired reduction or elimination. The ranges of log10-reduction were 0.38 (58%) to a complete eradication (100%) for P. gingivalis, 0.21 (39%) to 100% for A. actinomycetemcomitans and 0.3 (50%) to 100% for F. nucleatum. In conclusion, further and particularly more comparable studies are needed to evaluate if PDT can be clinically successful as an adjuvant in periodontal therapy. View Full-Text
Keywords: PDT; photodynamic therapy; in vitro; periodontitis; antimicrobial activity PDT; photodynamic therapy; in vitro; periodontitis; antimicrobial activity
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Haag, P.A.; Steiger-Ronay, V.; Schmidlin, P.R. The in Vitro Antimicrobial Efficacy of PDT against Periodontopathogenic Bacteria. Int. J. Mol. Sci. 2015, 16, 27327-27338.

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