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Recent Progress on Liver Kinase B1 (LKB1): Expression, Regulation, Downstream Signaling and Cancer Suppressive Function

School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, China
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2014, 15(9), 16698-16718;
Received: 4 July 2014 / Revised: 12 August 2014 / Accepted: 28 August 2014 / Published: 19 September 2014
(This article belongs to the Section Biochemistry)
PDF [944 KB, uploaded 19 September 2014]


Liver kinase B1 (LKB1), known as a serine/threonine kinase, has been identified as a critical cancer suppressor in many cancer cells. It is a master upstream kinase of 13 AMP-activated protein kinase (AMPK)-related protein kinases, and possesses versatile biological functions. LKB1 gene is mutated in many cancers, and its protein can form different protein complexes with different cellular localizations in various cell types. The expression of LKB1 can be regulated through epigenetic modification, transcriptional regulation and post-translational modification. LKB1 dowcnstream pathways mainly include AMPK, microtubule affinity regulating kinase (MARK), salt-inducible kinase (SIK), sucrose non-fermenting protein-related kinase (SNRK) and brain selective kinase (BRSK) signalings, etc. This review, therefore, mainly discusses recent studies about the expression, regulation, downstream signaling and cancer suppressive function of LKB1, which can be helpful for better understanding of this molecular and its significance in cancers. View Full-Text
Keywords: liver kinase B1; LKB1; cancer; AMPK; MARK liver kinase B1; LKB1; cancer; AMPK; MARK

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Gan, R.-Y.; Li, H.-B. Recent Progress on Liver Kinase B1 (LKB1): Expression, Regulation, Downstream Signaling and Cancer Suppressive Function. Int. J. Mol. Sci. 2014, 15, 16698-16718.

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