Next Article in Journal
Imaging of a Cilioretinal Artery Embolisation
Next Article in Special Issue
Small Engine, Big Power: MicroRNAs as Regulators of Cardiac Diseases and Regeneration
Previous Article in Journal
EPAS-1 Mediates SP-1-Dependent FBI-1 Expression and Regulates Tumor Cell Survival and Proliferation
Previous Article in Special Issue
MicroRNAs, Genomic Instability and Cancer
Article Menu
Issue 9 (September) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2014, 15(9), 15700-15733;

Multistep Model of Cervical Cancer: Participation of miRNAs and Coding Genes

Laboratorio de microRNAs, Unidad Académica de Ciencias Biológicas, Universidad Autónoma de Zacatecas, Av. Preparatoria S/N, Zacatecas 98066, Mexico
Académica de Ciencias Básicas, Doctorado de Ciencias Básicas, Universidad Autónoma de Zacatecas, Av. Preparatoria S/N, Campus II, Zacatecas 98066, Mexico
Author to whom correspondence should be addressed.
Received: 20 June 2014 / Revised: 5 August 2014 / Accepted: 13 August 2014 / Published: 4 September 2014
(This article belongs to the Collection Regulation by Non-Coding RNAs)
PDF [2177 KB, uploaded 4 September 2014]


Aberrant miRNA expression is well recognized as an important step in the development of cancer. Close to 70 microRNAs (miRNAs) have been implicated in cervical cancer up to now, nevertheless it is unknown if aberrant miRNA expression causes the onset of cervical cancer. One of the best ways to address this issue is through a multistep model of carcinogenesis. In the progression of cervical cancer there are three well-established steps to reach cancer that we used in the model proposed here. The first step of the model comprises the gene changes that occur in normal cells to be transformed into immortal cells (CIN 1), the second comprises immortal cell changes to tumorigenic cells (CIN 2), the third step includes cell changes to increase tumorigenic capacity (CIN 3), and the final step covers tumorigenic changes to carcinogenic cells. Altered miRNAs and their target genes are located in each one of the four steps of the multistep model of carcinogenesis. miRNA expression has shown discrepancies in different works; therefore, in this model we include miRNAs recording similar results in at least two studies. The present model is a useful insight into studying potential prognostic, diagnostic, and therapeutic miRNAs. View Full-Text
Keywords: miRNAs; cervical intraepithelial neoplasia (CIN); cervical cancer miRNAs; cervical intraepithelial neoplasia (CIN); cervical cancer

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Granados López, A.J.; López, J.A. Multistep Model of Cervical Cancer: Participation of miRNAs and Coding Genes. Int. J. Mol. Sci. 2014, 15, 15700-15733.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top